Cited 174 times in
Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박채규 | - |
dc.date.accessioned | 2016-02-19T11:28:50Z | - |
dc.date.available | 2016-02-19T11:28:50Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0953-8178 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143233 | - |
dc.description.abstract | DC-SIGN, a human C-type lectin, is expressed on the surface of dendritic cells (DC), while a closely related human gene, DC-SIGNR or L-SIGN, is found on sinusoidal endothelial cells of liver and lymph node. Both DC-SIGN and DC-SIGNR/L-SIGN can bind ICAM-3 and HIV gp120, and transmit HIV to susceptible cells in trans. Here, we report the cloning of five mouse genes homologous to human DC-SIGN and DC-SIGNR/L-SIGN. Only one gene, named mouse DC-SIGN, is highly expressed in DC, and is not found in a panel of mouse macrophage and lymphocyte cell lines. The other four genes, named mouse SIGNR1 (SIGN-Related gene 1), SIGNR2, SIGNR3 and SIGNR4, are expressed at lower levels in various cells according to RT-PCR and Northern blot analyses on RNA. All the genes of mouse DC-SIGN and SIGNRs map to adjacent regions of chromosome 8 A1.2–1.3. However, like human DC-SIGN, only the mouse DC-SIGN gene is closely juxtaposed to the CD23 gene, while the other four SIGNR genes are located close to each other in a neighboring region. mRNAs of mouse DC-SIGN and three SIGNR genes encode type II transmembrane proteins (DC-SIGN, 238 amino acids; SIGNR1, 325 amino acids; SIGNR3, 237 amino acids; SIGNR4, 208 amino acids), but the SIGNR2 gene only encodes a carbohydrate recognition domain (CRD) without a cytosolic domain and a transmembrane domain (SIGNR2, 178 amino acids). Amino acid sequence similarities between the CRD of human DC-SIGN and the mouse homologues are 67% for DC-SIGN, 69% for SIGNR1, 65% for SIGNR2, 68% for SIGNR3 and 70% for SIGNR4 respectively. However, the membrane proximal neck domains in the mouse genes are much shorter than their counterparts in human DC-SIGN and DC-SIGNR/L-SIGN. This family of mouse C-type lectins is therefore complex, but only one of the new genes, DC-SIGN, is juxtaposed to CD23 and is expressed at high levels in DC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1283~1290 | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Adhesion Molecules* | - |
dc.subject.MESH | Cloning, Molecular | - |
dc.subject.MESH | DNA, Complementary | - |
dc.subject.MESH | Dendritic Cells* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lectins/genetics* | - |
dc.subject.MESH | Lectins/isolation & purification | - |
dc.subject.MESH | Lectins, C-Type* | - |
dc.subject.MESH | Mice/genetics* | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Receptors, Cell Surface/genetics* | - |
dc.subject.MESH | Receptors, Cell Surface/isolation & purification | - |
dc.subject.MESH | Receptors, IgE/genetics | - |
dc.subject.MESH | Receptors, IgE/isolation & purification | - |
dc.subject.MESH | Sequence Homology, Amino Acid | - |
dc.subject.MESH | Spleen/cytology | - |
dc.subject.MESH | Tissue Distribution | - |
dc.title | Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Chae Gyu Park | - |
dc.contributor.googleauthor | Kazuhiko Takahara | - |
dc.contributor.googleauthor | Eiji Umemoto | - |
dc.contributor.googleauthor | Yusuke Yashima | - |
dc.contributor.googleauthor | Kazumi Matsubara | - |
dc.contributor.googleauthor | Yoichi Matsuda | - |
dc.contributor.googleauthor | Bjoern E. Clausen | - |
dc.contributor.googleauthor | Kayo Inaba | - |
dc.contributor.googleauthor | Ralph M. Steinman | - |
dc.identifier.doi | 10.1093/intimm/13.10.1283 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01718 | - |
dc.relation.journalcode | J01080 | - |
dc.identifier.eissn | 1460-2377 | - |
dc.identifier.pmid | 11581173 | - |
dc.contributor.alternativeName | Park, Chae Gyu | - |
dc.contributor.affiliatedAuthor | Park, Chae Gyu | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 13 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1283 | - |
dc.citation.endPage | 1290 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOLOGY, Vol.13(10) : 1283-1290, 2001 | - |
dc.identifier.rimsid | 39157 | - |
dc.type.rims | ART | - |
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