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The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation: Importance of Two Widely Separated IL-2 Response Elements
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형표 | - |
dc.date.accessioned | 2016-02-19T11:27:58Z | - |
dc.date.available | 2016-02-19T11:27:58Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143204 | - |
dc.description.abstract | The interleukin-2 receptor α (IL-2Rα) chain is an essential component of high-affinity IL-2 receptors. Accordingly, IL-2Rα expression helps to regulate T cell growth and other lymphoid functions. Lineage-restricted and activation-dependent IL-2Rα transcription is controlled by three upstream positive regulatory regions (PRRs). We now describe an additional IL-2 response element, PRRIV, within intron 1, in humans and mice. PRRIV activity requires GAS motifs that bind Stat5 proteins and additional upstream HMG-I(Y) binding sites. Moreover, IL-2 induces the binding of HMG-I(Y), Stat5a, and Stat5b in vivo to PRRIV and PRRIII, which also functions as an IL-2 response element. Thus, the IL-2 inducibility of the IL-2Rα gene is unexpectedly mediated by two widely separated regulatory Stat5-dependent elements, located both upstream and downstream of the transcription initiation sites. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 159~172 | - |
dc.relation.isPartOf | IMMUNITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amino Acid Motifs | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | DNA-Binding Proteins/metabolism | - |
dc.subject.MESH | Deoxyribonuclease I/pharmacology | - |
dc.subject.MESH | Gene Expression Regulation/drug effects* | - |
dc.subject.MESH | HMGA1a Protein | - |
dc.subject.MESH | High Mobility Group Proteins/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-2/pharmacology* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Milk Proteins* | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Receptors, Interleukin-2/genetics* | - |
dc.subject.MESH | Response Elements* | - |
dc.subject.MESH | STAT5 Transcription Factor | - |
dc.subject.MESH | Trans-Activators/metabolism | - |
dc.subject.MESH | Transcription Factors/metabolism | - |
dc.subject.MESH | Tumor Suppressor Proteins | - |
dc.title | The Basis for IL-2-Induced IL-2 Receptor α Chain Gene Regulation: Importance of Two Widely Separated IL-2 Response Elements | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Hyoung-Pyo Kim | - |
dc.contributor.googleauthor | John Kelly | - |
dc.contributor.googleauthor | Warren J. Leonard | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01163 | - |
dc.relation.journalcode | J01034 | - |
dc.identifier.eissn | 1097-4180 | - |
dc.identifier.pmid | 11485747 | - |
dc.contributor.alternativeName | Kim, Hyoung Pyo | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Pyo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 159 | - |
dc.citation.endPage | 172 | - |
dc.identifier.bibliographicCitation | IMMUNITY, Vol.15(1) : 159-172, 2001 | - |
dc.identifier.rimsid | 39138 | - |
dc.type.rims | ART | - |
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