Cited 8 times in
Lysophosphatidylcholine Decreases Delayed Rectifier K+ Current in Rabbit Coronary Smooth Muscle Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남택상 | - |
dc.contributor.author | 안덕선 | - |
dc.date.accessioned | 2016-02-19T11:24:33Z | - |
dc.date.available | 2016-02-19T11:24:33Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0916-7250 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143080 | - |
dc.description.abstract | Lysophosphatidylcholine (LPC), which exists abundantly in lipid fraction of oxidized low density lipoprotein, has been implicated in enhanced agonist-induced contraction and increase of intracellular Ca2+. The effect of LPC on the activity of delayed rectifier K+ current (IdK), which is a major determinant of membrane potential and vascular tone under resting condition, was examined in rabbit coronary smooth muscle cells using whole cell patch clamping technique. Application of LPC to the bath solution caused a concentration-dependent inhibition of IdK, and the concentration to produce half-maximal inhibition was 1.51 μM. This effect of LPC on IdK was readily reversed after washout of LPC in the bath. The steady-state voltage dependence of IdK was shifted to positive direction by both extra- and intracellular application of LPC. Staurosporine (100 nM) pretreatment significantly suppressed the LPC-induced inhibition of IdK. These results suggest that LPC inhibits IdK in rabbit coronary smooth muscle cells by a pathway that involves protein kinase C, and the LPC-induced inhibition of IdK may be, at least in part, responsible for the abnormal vascular reactivity in atherosclerotic coronary artery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 395~399 | - |
dc.relation.isPartOf | JOURNAL OF VETERINARY MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Coronary Vessels/cytology | - |
dc.subject.MESH | Coronary Vessels/drug effects | - |
dc.subject.MESH | Coronary Vessels/physiology | - |
dc.subject.MESH | Drug Antagonism | - |
dc.subject.MESH | Enzyme Inhibitors | - |
dc.subject.MESH | Lysophosphatidylcholines/antagonists & inhibitors | - |
dc.subject.MESH | Lysophosphatidylcholines/pharmacology* | - |
dc.subject.MESH | Membrane Potentials/drug effects | - |
dc.subject.MESH | Membrane Potentials/physiology | - |
dc.subject.MESH | Muscle, Smooth, Vascular/drug effects* | - |
dc.subject.MESH | Muscle, Smooth, Vascular/enzymology | - |
dc.subject.MESH | Muscle, Smooth, Vascular/physiology | - |
dc.subject.MESH | Patch-Clamp Techniques | - |
dc.subject.MESH | Peptides/pharmacology | - |
dc.subject.MESH | Potassium Channel Blockers* | - |
dc.subject.MESH | Potassium Channels/physiology | - |
dc.subject.MESH | Protein Kinase C/physiology | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Staurosporine/pharmacology | - |
dc.title | Lysophosphatidylcholine Decreases Delayed Rectifier K+ Current in Rabbit Coronary Smooth Muscle Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Dongsoo YEON | - |
dc.contributor.googleauthor | Seongchun KWON | - |
dc.contributor.googleauthor | Taicksang NAM | - |
dc.contributor.googleauthor | Ducksun AHN | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01271 | - |
dc.contributor.localId | A02223 | - |
dc.relation.journalcode | J01926 | - |
dc.identifier.eissn | 1347-7439 | - |
dc.identifier.pmid | 11346173 | - |
dc.subject.keyword | coronary smooth muscle | - |
dc.subject.keyword | delayed rectifier K+ current | - |
dc.subject.keyword | lysophosphatidylcholine | - |
dc.subject.keyword | protein kinase C | - |
dc.contributor.alternativeName | Nam, Taick Sang | - |
dc.contributor.alternativeName | Ahn, Duk Sun | - |
dc.contributor.affiliatedAuthor | Nam, Taick Sang | - |
dc.contributor.affiliatedAuthor | Ahn, Duk Sun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 63 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 395 | - |
dc.citation.endPage | 399 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VETERINARY MEDICAL SCIENCE, Vol.63(4) : 395-399, 2001 | - |
dc.identifier.rimsid | 39007 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.