Cited 71 times in
Low-dose growth hormone treatment combined with diet restriction decreases insulin resistance by reducing visceral fat and increasing muscle mass in obese type 2 diabetic patients
DC Field | Value | Language |
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dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2016-02-19T11:24:29Z | - |
dc.date.available | 2016-02-19T11:24:29Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0307-0565 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143078 | - |
dc.description.abstract | OBJECTIVE: To evaluate the effects of low-dose growth hormone (GH) therapy combined with diet restriction on changes in body composition and the consequent change in insulin resistance in newly-diagnosed obese type 2 diabetic patients. DESIGN: Double-blind and placebo-controlled trial of 25-kcal/kg IBW diet daily with GH (n=9; rhGH, 0.15 IU/kg body weight/week) or placebo (n=9) for 12 weeks. SUBJECTS: Eighteen newly-diagnosed obese type 2 diabetic patients (age 42--56 y, body mass index 28.1+/-2.7 kg/m(2)). MEASUREMENTS: Body composition and fat distribution parameters (by bioelectrical impedance analyzer and CT scans), serum IGF-1; serum glucose, insulin and free fatty acid (FFA) during oral glucose tolerance test (OGTT); HbA(1c); serum lipid profiles; and glucose disposal rate (GDR) by euglycemic hyperinsulinemic clamp at baseline and after treatment. RESULTS: The fraction of body weight lost as fat lost was significantly greater (0.98+/-0.39 vs 0.52+/-0.32 kg/kg, P<0.05) and visceral fat area was decreased more in the GH-treated group compared to the placebo-treated group (27.9 vs 21.6%, P<0.05). Lean body mass and muscle area were reduced in the placebo-treated group, whereas an increase in both was observed in the GH-treated group. GDR the was significantly increased in only the GH-treated group (4.67+/-1.05 vs 6.95+/-0.91 mg/kg/min, P<0.05). The GH-induced increase in GDR was positively correlated with the decrease in the ratio of visceral fat area/muscle area (r=0.588, P=0.001). Serum glucose levels and insulin- and FFA-area under the curve during OGTT and HbA(1c) were significantly decreased after GH treatment. LDL-cholesterol level was decreased in only the GH-treated group. CONCLUSION: Low-dose GH treatment combined with dietary restriction resulted not only in a decrease of visceral fat but also in an increase of muscle mass with a consequent improvement of the insulin resistance observed in obese type 2 diabetic patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1101~1107 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF OBESITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adipose Tissue/metabolism* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Blood Glucose/metabolism | - |
dc.subject.MESH | Body Composition/drug effects* | - |
dc.subject.MESH | Diabetes Mellitus/metabolism | - |
dc.subject.MESH | Diabetes Mellitus/therapy* | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/metabolism | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/therapy* | - |
dc.subject.MESH | Diet, Reducing* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glucose Clamp Technique | - |
dc.subject.MESH | Glucose Tolerance Test | - |
dc.subject.MESH | Growth Hormone/therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance | - |
dc.subject.MESH | Lipids/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Muscle, Skeletal/metabolism | - |
dc.subject.MESH | Obesity* | - |
dc.title | Low-dose growth hormone treatment combined with diet restriction decreases insulin resistance by reducing visceral fat and increasing muscle mass in obese type 2 diabetic patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | S Y Nam | - |
dc.contributor.googleauthor | K R Kim | - |
dc.contributor.googleauthor | B S Cha | - |
dc.contributor.googleauthor | Y D Song | - |
dc.contributor.googleauthor | S K Lim | - |
dc.contributor.googleauthor | H C Lee | - |
dc.contributor.googleauthor | K B Huh | - |
dc.identifier.doi | 10.1038/sj.ijo.0801636 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03996 | - |
dc.relation.journalcode | J01140 | - |
dc.identifier.eissn | 1476-5497 | - |
dc.identifier.pmid | 11477493 | - |
dc.identifier.url | http://www.nature.com/ijo/journal/v25/n8/full/0801636a.html | - |
dc.subject.keyword | growth hormone | - |
dc.subject.keyword | visceral fat | - |
dc.subject.keyword | insulin resistance | - |
dc.subject.keyword | type 2 diabetes mellitus | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1101 | - |
dc.citation.endPage | 1107 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF OBESITY, Vol.25(8) : 1101-1107, 2001 | - |
dc.identifier.rimsid | 39005 | - |
dc.type.rims | ART | - |
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