Cited 5 times in
Lipopolysaccharide Temporarily Impairs Sphincter of Oddi Motility
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박효진 | - |
dc.date.accessioned | 2016-02-19T11:24:18Z | - |
dc.date.available | 2016-02-19T11:24:18Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1089-8603 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143071 | - |
dc.description.abstract | The aim of our study was to determine the effect of lipopolysaccharide (LPS) on sphincter of Oddi (SO) motility. Opossums received saline, Escherichia coli LPS (1.0 mg/kg), or E. coli LPS (1.0 mg/kg) and aminoguanidine (50 mg/kg), and the SO was removed 6–24 h later. At 12 h LPS decreased electrical field stimulation (EFS)-induced relaxation and increased baseline tone. These changes were reversed when the animals were pretreated with aminoguanidine. The dose-dependent decrease in EFS-induced relaxation by Nω-nitro--arginine was impaired after LPS, but not in animals that received LPS and aminoguanidine. The impaired EFS-induced relaxation after LPS was reversed when -arginine was added to the tissue bath. Serum levels of NO−2/NO−3 were increased with LPS as compared to saline or both LPS and aminoguanidine. Inducible nitric oxide synthase mRNA was readily seen in SO segments after LPS. LPS impairs EFS-induced relaxation and increases baseline tone of the SO. The effects of LPS on SO motility appear to be mediated by nitric oxide. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 547~554 | - |
dc.relation.isPartOf | NITRIC OXIDE-BIOLOGY AND CHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | DNA Primers | - |
dc.subject.MESH | Electric Stimulation | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Enzymologic/drug effects | - |
dc.subject.MESH | Lipopolysaccharides/pharmacology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nitric Acid/metabolism | - |
dc.subject.MESH | Nitric Oxide Synthase/genetics | - |
dc.subject.MESH | Opossums | - |
dc.subject.MESH | Sphincter of Oddi/drug effects* | - |
dc.subject.MESH | Sphincter of Oddi/enzymology | - |
dc.subject.MESH | Sphincter of Oddi/metabolism | - |
dc.subject.MESH | Sphincter of Oddi/physiology | - |
dc.title | Lipopolysaccharide Temporarily Impairs Sphincter of Oddi Motility | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Joseph J. Cullen | - |
dc.contributor.googleauthor | Hyojin Park | - |
dc.contributor.googleauthor | Kimberly S. Ephgrave | - |
dc.contributor.googleauthor | Jeffrey L. Conklin | - |
dc.identifier.doi | 10.1006/niox.2001.0380 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01774 | - |
dc.relation.journalcode | J02375 | - |
dc.identifier.eissn | 1089-8611 | - |
dc.identifier.pmid | 11730361 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1089860301903805?np=y | - |
dc.subject.keyword | sphincter of Oddi motility | - |
dc.contributor.alternativeName | Park, Hyo Jin | - |
dc.contributor.affiliatedAuthor | Park, Hyo Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 5 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 547 | - |
dc.citation.endPage | 554 | - |
dc.identifier.bibliographicCitation | NITRIC OXIDE-BIOLOGY AND CHEMISTRY, Vol.5(6) : 547-554, 2001 | - |
dc.identifier.rimsid | 38998 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.