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Hepatitis B Virus X Protein Induced Expression of the Nur77 Gene

Authors
 Mi-Ock Lee  ;  Hyo-Jin Kang  ;  Hyeseong Cho  ;  Eui-Cheol Shin  ;  Jeon Han Park  ;  Se Jong Kim 
Citation
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.288(5) : 1162-1168, 2001 
Journal Title
 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 
ISSN
 0006-291X 
Issue Date
2001
MeSH
Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism* ; Carcinoma, Hepatocellular/virology ; DNA-Binding Proteins/biosynthesis* ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/physiology ; Fas Ligand Protein ; Hepatitis B/genetics ; Hepatitis B/metabolism* ; Hepatitis B/virology ; Hepatitis B virus/genetics ; Humans ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism* ; Liver Neoplasms/virology ; Membrane Glycoproteins/biosynthesis ; Membrane Glycoproteins/genetics ; Mutation ; Nuclear Receptor Subfamily 4, Group A, Member 1 ; Oligonucleotides, Antisense/pharmacology ; Promoter Regions, Genetic ; RNA, Messenger/biosynthesis ; Receptors, Cytoplasmic and Nuclear ; Receptors, Steroid ; Trans-Activators/biosynthesis ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Trans-Activators/pharmacology* ; Trans-Activators/physiology ; Transcription Factors/biosynthesis* ; Transcription Factors/genetics ; Transcription Factors/physiology ; Transcriptional Activation* ; Transfection ; Tumor Cells, Cultured ; Virus Integration
Abstract
Hepatitis B virus (HBV) X protein (HBx) plays an essential role in development of HBV-associated hepatocellular carcinoma (HCC). Recently, we reported that HBx induces Fas Ligand (FasL) expression, which may help HCC cells to evade host-immune surveillance. The aim of this study was to investigate the role of HBx in expression of Nur77, an orphan nuclear receptor implicated in the upregulation of FasL. When Chang X-34 expressing HBx under the control of a doxycycline-inducible promoter was examined, induction of Nur77 was observed following HBx expression. Blocking of Nur77 function by introduction of an antisense or a dominant negative mutant Nur77 significantly inhibited the induction of FasL, indicating that Nur77 plays critical roles in FasL expression. Further, a high-level expression of transcripts and DNA binding of Nur77 were observed in the HBV-integrated cell lines established from HCC patients that express HBx. These results suggested that Nur77 may contribute to leading the HBx-induced Fas/FasL signaling pathway which eliminates invading Fas-expressing lymphocytes.
Full Text
http://www.sciencedirect.com/science/article/pii/S0006291X01959108
DOI
10.1006/bbrc.2001.5910
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Jong(김세종)
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143061
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