131 125

Cited 24 times in

Role of skin prick test and serological measurement of specific IgE in the diagnosis of occupational asthma resulting from exposure to vinyl sulphone reactive dyes

DC FieldValueLanguage
dc.contributor.author박중원-
dc.contributor.author홍천수-
dc.date.accessioned2016-02-19T11:23:57Z-
dc.date.available2016-02-19T11:23:57Z-
dc.date.issued2001-
dc.identifier.issn1351-0711-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/143058-
dc.description.abstractOBJECTIVES: Some patients with occupational asthma resulting from exposure to reactive dyes have skin reactivity to the causative dyes and specific IgE to reactive dyes have been found in these patients. However, the usefulness of skin prick tests (SPTs) and serological measurement of specific IgE in screening, diagnosis, and monitoring the occupational asthma resulting from exposure to reactive dyes have not yet been assessed. In this study, the clinical validation of SPTs and measurement of specific IgE to vinyl sulphone reactive dyes by enzyme linked immunosorbent assay (ELISA) was evaluated. METHODS: 42 Patients with occupational asthma from reactive dyes (true positive group) were enrolled. In these the causative reactive dye was confirmed by bronchial challenge test. 93 Asymptomatic factory workers with negative challenge to the reactive dye (true negative group) and 16 unexposed controls with negative challenge to the reactive dye were also enrolled. Skin prick tests were done with 10 mg/ml reactive dye in 0.4% phenol/0.9% saline. IgE specific to reactive dye conjugated to human serum albumin (HSA) was measured with enzyme linked immunosorbent assays (ELISAs). RESULTS: None of the unexposed controls had a positive response to SPTs. The sensitivity (76.2% v 53.7%), specificity (91.4% v 86.0%), positive predictive value (80.0% v 62.9%), and negative predictive value (89.5% v 80.8%) of SPTs were higher than those of ELISAs. The mean weal size of reaction to reactive dye was weakly correlated with the ELISA optical density of IgE to reactive dye conjugate in patients with occupational asthma from reactive dyes (n=41, r=0.337, p<0.05). In four patients with occupational asthma from reactive dyes and eight control subjects exposed to reactive dye, IgE specific to reactive dye conjugated to HSA was detected with ELISA even though they showed negative skin reactivity. Six patients completely avoided the reactive dye for a mean (SD) 27.8 (10.3) months, IgE specific to reactive dyes decreased in all six patients (p<0.05) during this time. CONCLUSIONS: Both SPTs and detection of IgE specific to reactive dye in serum samples could be valuable for screening, diagnosis, and monitoring occupational asthma resulting from exposure to reactive dyes. These two tests would complement each other.-
dc.description.statementOfResponsibilityopen-
dc.format.extent411~416-
dc.relation.isPartOfOCCUPATIONAL AND ENVIRONMENTAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAsthma/chemically induced-
dc.subject.MESHAsthma/diagnosis*-
dc.subject.MESHBronchial Provocation Tests/methods-
dc.subject.MESHColoring Agents/adverse effects*-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin E/blood*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOccupational Diseases/chemically induced-
dc.subject.MESHOccupational Diseases/diagnosis*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSkin Tests/methods*-
dc.subject.MESHSulfones/adverse effects*-
dc.subject.MESHSulfones/immunology-
dc.titleRole of skin prick test and serological measurement of specific IgE in the diagnosis of occupational asthma resulting from exposure to vinyl sulphone reactive dyes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJ Park-
dc.contributor.googleauthorC Kim-
dc.contributor.googleauthorK Kim-
dc.contributor.googleauthorS Choi-
dc.contributor.googleauthorD Kang-
dc.contributor.googleauthorS Ko-
dc.contributor.googleauthorJ Won-
dc.contributor.googleauthorJ Yang-
dc.contributor.googleauthorC Hong-
dc.identifier.doi10.1136/oem.58.6.411-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01681-
dc.contributor.localIdA04448-1-
dc.relation.journalcodeJ02410-
dc.identifier.eissn1470-7926-
dc.identifier.pmid11351058-
dc.subject.keywordreactive dye-
dc.subject.keywordoccupational asthma-
dc.subject.keywordskin prick test-
dc.contributor.alternativeNamePark, Jung Won-
dc.contributor.alternativeNameHong, Chein Soo-
dc.contributor.affiliatedAuthorPark, Jung Won-
dc.contributor.affiliatedAuthorHong, Chein Soo-
dc.rights.accessRightsfree-
dc.citation.volume58-
dc.citation.number6-
dc.citation.startPage411-
dc.citation.endPage416-
dc.identifier.bibliographicCitationOCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol.58(6) : 411-416, 2001-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.