Propofol 마취유도시의 자발적 움직임에 관한 임상 연구

Abstract

Background: Spontaneous movements during anesthetic induction with propofol are a relatively common side effect and related with the loading dose, infusion rates and pain on injection. This study was performed prospectively to evaluate the incidence of abnormal movement and the infused dose of propofol at the time of movement.

Methods: 240 children (1∼15 yrs of age, ASA physical status Ⅰ,Ⅱ) and 100 adults (16∼80 yrs of age, ASA physical status Ⅰ,Ⅱ) undergoing a short duration of ENT or EYE procedures were included. During the infusion of propofol, an independent anesthesiologist graded the spontaneous abnormal movements from 0 to 2 and the dose of propofol at that time.

Results: The incidence of spontaneous movements were 32.5% (78/240) and 4.0% (4/100) in children and adults respectively (p<0.05). The infused dose of propofol at the time of movement were 2.0±0.5㎎/㎏ and 1.5±0.2㎎/㎏ in children and adults respectively.

Conclusions: Our results of the pilot prospective survey demonstrated that spontaneous movements are more common in children related with lower infusion rates during induction of propofol and the characteristic volume of distribution in children compared to adults.