Cited 26 times in
Implication of the Small GTPase Rac1 in the Apoptosis Induced by UV in Rat-2 Fibroblasts
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황기철 | - |
dc.date.accessioned | 2016-02-19T11:23:36Z | - |
dc.date.available | 2016-02-19T11:23:36Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143045 | - |
dc.description.abstract | Exposure of mammalian cells to ultraviolet (UV) light elicits a cellular response and also lead to apoptotic cell death. However, the role of Rac, a member of Rho family GTPases, in the UV-induced apoptosis has never been examined. In UV-irradiated Rat-2 fibroblasts, nuclear fragmentation began to be observed within 2 h and the total viability of Rat-2 cells were only about 15% at 6 h following by UV irradiation, whereas the total viability in Rat2-RacN17 cells stably expressing RacN17, a dominant negative Rac1 mutant, was almost close to 67%. Pretreatment with SB203580, a specific inhibitor of p38 kinase, likewise attenuated UV-induced cell death, but PD98059, a MEK inhibitor, did not. Thus, Rac1 and p38 kinase appear to be components in the apoptotic signaling pathway induced by UV irradiation in Rat-2 fibroblasts. In addition, our results show that p38 kinase stimulation by UV is dramatically inhibited by RacN17, suggesting that p38 kinase is situated downstream of Rac1 in the UV signaling to apoptosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 825~829 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis* | - |
dc.subject.MESH | Bisbenzimidazole | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cell Survival/radiation effects | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology | - |
dc.subject.MESH | Fibroblasts/cytology | - |
dc.subject.MESH | Fibroblasts/metabolism* | - |
dc.subject.MESH | Fibroblasts/radiation effects* | - |
dc.subject.MESH | Fluorescent Dyes | - |
dc.subject.MESH | Genes, Dominant | - |
dc.subject.MESH | Imidazoles/pharmacology | - |
dc.subject.MESH | Mitogen-Activated Protein Kinases/antagonists & inhibitors | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Phosphorylation/drug effects | - |
dc.subject.MESH | Pyridines/pharmacology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Transfection | - |
dc.subject.MESH | Ultraviolet Rays* | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases | - |
dc.subject.MESH | rac1 GTP-Binding Protein/genetics | - |
dc.subject.MESH | rac1 GTP-Binding Protein/metabolism* | - |
dc.title | Implication of the Small GTPase Rac1 in the Apoptosis Induced by UV in Rat-2 Fibroblasts | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Young-Woo Eom | - |
dc.contributor.googleauthor | Min-Hyuk Yoo | - |
dc.contributor.googleauthor | Chang-Hoon Woo | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.contributor.googleauthor | Woo Keun Song | - |
dc.contributor.googleauthor | Yung-Joon Yoo | - |
dc.contributor.googleauthor | Jang Soo Chun | - |
dc.contributor.googleauthor | Jae-Hong Kim | - |
dc.identifier.doi | 10.1006/bbrc.2001.5233 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04456 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 11453667 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X01952337?np=y | - |
dc.subject.keyword | Rac | - |
dc.subject.keyword | p38 kinase | - |
dc.subject.keyword | UV | - |
dc.subject.keyword | apoptosis | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 285 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 825 | - |
dc.citation.endPage | 829 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.285(3) : 825-829, 2001 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.