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허쉬슈프렁병 환아의 무신경절 장관에서 Neural Cell Adhesion Molecule (NCAM) 과 Glial Cell Line-Derived Neurotrophic Factor (GDNF)의 발현

DC FieldValueLanguage
dc.contributor.author오정탁-
dc.contributor.author최승훈-
dc.contributor.author한석주-
dc.date.accessioned2016-02-19T11:22:58Z-
dc.date.available2016-02-19T11:22:58Z-
dc.date.issued2001-
dc.identifier.issn1225-9047-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/143022-
dc.description.abstractThe pathophysiology of Hirschsprung's disease (HD) is not fully understood, but recent studies have disclosed that neural cell adhesion molecule (NCAM) and glial cell line-derived neurotrophic factor (GDNF) play important roles in the formation of aganglionic bowel of Hirschsprung's disease. To evaluate the roles of NCAM and GDNF in HD, immunohistochemical analysis was performed using formalin-fixed and paraffin-embedded tissue sections. On the basis of the results, we tried to evaluate them as diagnostic markers. The specimens were obtained from 7 patients with HD who underwent modified Duhamel operation. The diagnosis was based on the clinical findings and the absence of ganglion cells in the nerve plexuses by routine microscopy. NCAM immunoreactivity was found in the nerve plexuses and scattered nerve fibers in the smooth muscle layers of ganglionic segments. In aganglionic segments, the number of NCAM positive nerve fibers in the smooth muscle layers was significantly reduced compared with ganglionic segments. In two cases the nerve plexuses in aganglionic segments, NCAM was negligible. The smooth muscle cells showed diffuse immunoreactivity for GDNF and the staining intensity was not different in the aganglionic and ganglionic segments. However, higher expression of GDNF in the nerve plexus of the ganglionic segments was noted comparing to aganglionic segments. These data suggest that both NCAM and GDNF may play important roles in pathogenesis of Hirschsprung's disease and immunohistochemical staining for NCAM can be used as an ancillary diagnostic tool for HD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent15~20-
dc.relation.isPartOfJournal of the Korean Association of Pediatric Surgeons (소아외과)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title허쉬슈프렁병 환아의 무신경절 장관에서 Neural Cell Adhesion Molecule (NCAM) 과 Glial Cell Line-Derived Neurotrophic Factor (GDNF)의 발현-
dc.title.alternativeExpression of Neural Cell Adhesion Molecule (NCAM) and Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Aganglionic Bowel of Hirschsprung's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthor오정탁-
dc.contributor.googleauthor한애리-
dc.contributor.googleauthor손석우-
dc.contributor.googleauthor최승훈-
dc.contributor.googleauthor한석주-
dc.contributor.googleauthor황의호-
dc.contributor.googleauthor양우익-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02397-
dc.contributor.localIdA04103-
dc.contributor.localIdA04288-
dc.relation.journalcodeJ01808-
dc.subject.keywordHirschsprung's disease-
dc.subject.keywordNeural cell adhesion molecule-
dc.subject.keywordGlial cell line-derived neurotrophic factor-
dc.contributor.alternativeNameOh, Jung Tak-
dc.contributor.alternativeNameChoi, Seung Hoon-
dc.contributor.alternativeNameHan, Seok Joo-
dc.contributor.affiliatedAuthorOh, Jung Tak-
dc.contributor.affiliatedAuthorChoi, Seung Hoon-
dc.contributor.affiliatedAuthorHan, Seok Joo-
dc.contributor.affiliatedAuthor오정탁-
dc.rights.accessRightsfree-
dc.citation.volume7-
dc.citation.number1-
dc.citation.startPage15-
dc.citation.endPage20-
dc.identifier.bibliographicCitationJournal of the Korean Association of Pediatric Surgeons (소아외과), Vol.7(1) : 15-20, 2001-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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