179 272

Cited 0 times in

Chromosome Polysomy and Histological Characteristics in Oral Premalignant Lesions

DC FieldValueLanguage
dc.contributor.author김진-
dc.date.accessioned2016-02-19T11:19:07Z-
dc.date.available2016-02-19T11:19:07Z-
dc.date.issued2001-
dc.identifier.issn1055-9965-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142879-
dc.description.abstractHead and neck tumorigenesis has been postulated to represent a multistep process driven by the accumulation of carcinogen-induced genetic changes throughout the exposed tissue field. To better explore this genetic instability process at the tissue level, 59 regions within 26 biopsy tissue specimens from individuals with oral leukoplakia have been subjected to chromosome 9 in situ hybridization analysis, and the degree of chromosome instability was related to known clinical/pathological parameters associated with tumor risk. Whereas chromosome indices were similar between high-risk lesion sites and low-risk lesion sites, high-risk lesions showed higher levels of chromosome polysomy than did low-risk sites [median PIs (polysomy indices), 2.1 versus 1.4, respectively]. Similarly, dysplastic regions showed significantly higher chromosome polysomy levels than hyperplastic regions (median PIs, 2.4 versus 1.5, respectively). Interestingly, however, hyperplastic regions in the same biopsy as dysplastic regions showed two-times higher polysomy levels than those in biopsies without dysplasia (median PIs, 2.6 versus 1.3, respectively), suggesting that chromosome polysomy determinations provide a field measurement for the degree of ongoing genetic insult. Finally, chromosome polysomy tended to persist or increase in the superficial epithelial layers in regions showing koilocytosis, whereas their frequency decreased in nonkoilocytotic regions, suggesting that epigenetic factors may serve to perpetuate the levels of genetically unstable cells in the epithelium. These results provide direct support for the field cancerization process and suggest that measurements of genetic instability might provide additional biological information beyond histology and lesion site characteristics in the assessment of head and neck cancer risk.-
dc.description.statementOfResponsibilityopen-
dc.format.extent319~325-
dc.relation.isPartOfCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAneuploidy*-
dc.subject.MESHBiomarkers, Tumor/analysis*-
dc.subject.MESHBiopsy-
dc.subject.MESHCell Transformation, Neoplastic*-
dc.subject.MESHChromosomes, Human, Pair 9/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyperplasia-
dc.subject.MESHIn Situ Hybridization-
dc.subject.MESHLeukoplakia, Oral/genetics*-
dc.subject.MESHLeukoplakia, Oral/pathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrecancerous Conditions/genetics*-
dc.subject.MESHPrecancerous Conditions/pathology-
dc.subject.MESHRisk Factors-
dc.titleChromosome Polysomy and Histological Characteristics in Oral Premalignant Lesions-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학)-
dc.contributor.googleauthorJin Kim-
dc.contributor.googleauthorDong M. Shin-
dc.contributor.googleauthorAdel El-Naggar-
dc.contributor.googleauthorJin S. Lee-
dc.contributor.googleauthorCarmen Corrales-
dc.contributor.googleauthorScott M. Lippman-
dc.contributor.googleauthorWaun K. Hong-
dc.contributor.googleauthorWalter N. Hittelman-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01009-
dc.relation.journalcodeJ00441-
dc.identifier.eissn1538-7755-
dc.identifier.pmid11319171-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.affiliatedAuthorKim, Jin-
dc.rights.accessRightsfree-
dc.citation.volume10-
dc.citation.number4-
dc.citation.startPage319-
dc.citation.endPage325-
dc.identifier.bibliographicCitationCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, Vol.10(4) : 319-325, 2001-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.