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대뇌피질 발달기형이 동반된 소아간질의 임상 및 전기 생리학적 특징에 대한 연구
DC Field | Value | Language |
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dc.contributor.author | 김흥동 | - |
dc.date.accessioned | 2016-02-19T11:15:48Z | - |
dc.date.available | 2016-02-19T11:15:48Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1226-6965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142756 | - |
dc.description.abstract | Purpose: To evaluate the clinical and electrophysiological characteristics of malformation of cortical development (MCD) with epilepsy. Method: We studied clinical and electroencephalographic (EEG) features of 54 childhood epilepsy patients with MCD diagnosed by magnetic resonance imaging (MRI) and pathologic examinations. Results: 1) Bilateral diffuse MCD’s were in 5 patients, bilateral focal MCD’s were in 8, unilateral diffuse MCD’s in 7, and unilateral focal MCD’s were noted in 34 patients. 2) Partial seizures were manifested in 35 patients, and 4 of them evolve to infantile spasm (IS), isolated IS was noted in 15 cases, and generalized seizures were noticed in 2 cases 3) Asymmetric EEG backgraound slowing was noted in 30 patients, and 29 patients (96.7%) had MCD’s in abnormal side of brain. 4) Polymorphic slowing was noted in 36 patients, and 28 cases (77.8%) had MCD’s in those area. 5) Sensitivity of partial epileptiform discharges (ED’s) for MCD was 79.6%, but specificity was 68.5%. 6) Localized paroxysmal fast activity was noted in 16 cases (29.6%), and specificity for MCD was 90.7%. 7) Spindle shaped fast activity was noted in 8 patients (14.8%), and its specificity was 100%. 8) Thirty-one cases (57.4%) were intractable to antiepileptic drugs (AED’s). Seventeen cases of them were treated by ketogenic diet, and 12 patients (66.7%) were completely controlled. Among 12 cases of surgical resection, 11 patients (91.7%) became seizure free for 6 months to 2 years. 9) In pathologically confirmed cases, EEG sensitivity for MCD lesion was 100%, but sensitivity of MRI was 69.2%. Conclusion: EEG is most sensitive diagnostic tool for MCD in childhood epilepsy. and many of intractable epilepsy could be controlled by ketogenic diet and surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 10~17 | - |
dc.relation.isPartOf | Journal of Korean Epilepsy Society (대한간질학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 대뇌피질 발달기형이 동반된 소아간질의 임상 및 전기 생리학적 특징에 대한 연구 | - |
dc.title.alternative | Clinical and Electrophysiologic Characteristics of Malformation of Cortical Development with Childhood Epilepsy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | 이정수 | - |
dc.contributor.googleauthor | 박중채 | - |
dc.contributor.googleauthor | 김흥동 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01208 | - |
dc.relation.journalcode | J01509 | - |
dc.subject.keyword | malformation of cortical development | - |
dc.subject.keyword | electroencephalography | - |
dc.subject.keyword | ketogenic diet | - |
dc.contributor.alternativeName | Kim, Heung Dong | - |
dc.contributor.affiliatedAuthor | Kim, Heung Dong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 5 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 10 | - |
dc.citation.endPage | 17 | - |
dc.identifier.bibliographicCitation | Journal of Korean Epilepsy Society (대한간질학회지), Vol.5(1) : 10-17, 2001 | - |
dc.identifier.rimsid | 29822 | - |
dc.type.rims | ART | - |
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