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A Novel Approach to Cancer Therapy Using an Oncolytic Herpes Virus to Package Amplicons Containing Cytokine Genes

DC Field Value Language
dc.contributor.author김세헌-
dc.date.accessioned2016-02-19T11:15:28Z-
dc.date.available2016-02-19T11:15:28Z-
dc.date.issued2001-
dc.identifier.issn1525-0016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142744-
dc.description.abstractThere are two promising herpes viral-based anticancer strategies: one involves replication-defective viruses to transfer therapeutic transgenes, and the other involves replication-conditional oncolytic viruses, which selectively infect and destroy cancer cells directly. This study examines a novel dual herpesvirus preparation, which combines the immunostimulatory effects of amplicon-mediated IL2 expression with direct viral-induced oncolysis. The oncolytic virus G207 was used as the helper virus to package a herpes simplex virus (HSV)-amplicon vector carrying the gene IL2 (HSV-IL2), yielding a single preparation with two complementary modes of action. In vivo comparison was carried out in a syngeneic squamous cell carcinoma flank tumor model. We directly injected established tumors with HSV-IL2, G207, G207 mixed with HSV-IL2, or G207-packaged HSV-amplicon carrying the IL2 transgene (G207[IL2]). Significant inhibition of tumor growth was seen at 2 weeks in the G207[IL2]-treated tumors relative to controls (0.57plusminus0.44 cm3 versus 39.45plusminus5.13 cm3, P <0.00001), HSV-IL2 (20.97plusminus4.60 cm3), and the G207 group (7.71plusminus2.10 cm3). This unique use of a replication-conditional, oncolytic virus to package a replication-incompetent amplicon vector demonstrates impressive efficacy in vitro and in vivo, and avoids the theoretical concerns of recombination with reversion to wild type.-
dc.description.statementOfResponsibilityopen-
dc.format.extent250~256-
dc.relation.isPartOfMOLECULAR THERAPY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCD4-Positive T-Lymphocytes/immunology-
dc.subject.MESHCD8-Positive T-Lymphocytes/immunology-
dc.subject.MESHCarcinoma, Squamous Cell/genetics-
dc.subject.MESHCarcinoma, Squamous Cell/immunology-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCarcinoma, Squamous Cell/therapy-
dc.subject.MESHCell Death-
dc.subject.MESHCell Division-
dc.subject.MESHHumans-
dc.subject.MESHImmunotherapy*-
dc.subject.MESHInterleukin-2/genetics*-
dc.subject.MESHInterleukin-2/immunology*-
dc.subject.MESHInterleukin-2/metabolism-
dc.subject.MESHInterleukin-2/therapeutic use-
dc.subject.MESHMice-
dc.subject.MESHNeoplasms/genetics*-
dc.subject.MESHNeoplasms/immunology-
dc.subject.MESHNeoplasms/pathology-
dc.subject.MESHNeoplasms/therapy*-
dc.subject.MESHSimplexvirus/genetics*-
dc.subject.MESHTransfection-
dc.subject.MESHTumor Cells, Cultured-
dc.titleA Novel Approach to Cancer Therapy Using an Oncolytic Herpes Virus to Package Amplicons Containing Cytokine Genes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorJohn F. Carew-
dc.contributor.googleauthorDavid A. Kooby-
dc.contributor.googleauthorMarc W. Halterman-
dc.contributor.googleauthorSe-Heon Kim-
dc.contributor.googleauthorHoward J. Federoff-
dc.contributor.googleauthorYuman Fong-
dc.identifier.doi10.1006/mthe.2001.0448-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00605-
dc.relation.journalcodeJ02271-
dc.identifier.eissn1525-0024-
dc.identifier.pmid11545616-
dc.subject.keywordamplicon-
dc.subject.keywordherpes simplex virus type-1-
dc.subject.keywordinterleukin-2-
dc.subject.keywordoncolytic virus-
dc.contributor.alternativeNameKim, Se Heon-
dc.contributor.affiliatedAuthorKim, Se Heon-
dc.rights.accessRightsfree-
dc.citation.volume4-
dc.citation.number3-
dc.citation.startPage250-
dc.citation.endPage256-
dc.identifier.bibliographicCitationMOLECULAR THERAPY, Vol.4(3) : 250-256, 2001-
dc.identifier.rimsid29814-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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