Cited 60 times in
A Novel Approach to Cancer Therapy Using an Oncolytic Herpes Virus to Package Amplicons Containing Cytokine Genes
DC Field | Value | Language |
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dc.contributor.author | 김세헌 | - |
dc.date.accessioned | 2016-02-19T11:15:28Z | - |
dc.date.available | 2016-02-19T11:15:28Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1525-0016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142744 | - |
dc.description.abstract | There are two promising herpes viral-based anticancer strategies: one involves replication-defective viruses to transfer therapeutic transgenes, and the other involves replication-conditional oncolytic viruses, which selectively infect and destroy cancer cells directly. This study examines a novel dual herpesvirus preparation, which combines the immunostimulatory effects of amplicon-mediated IL2 expression with direct viral-induced oncolysis. The oncolytic virus G207 was used as the helper virus to package a herpes simplex virus (HSV)-amplicon vector carrying the gene IL2 (HSV-IL2), yielding a single preparation with two complementary modes of action. In vivo comparison was carried out in a syngeneic squamous cell carcinoma flank tumor model. We directly injected established tumors with HSV-IL2, G207, G207 mixed with HSV-IL2, or G207-packaged HSV-amplicon carrying the IL2 transgene (G207[IL2]). Significant inhibition of tumor growth was seen at 2 weeks in the G207[IL2]-treated tumors relative to controls (0.57plusminus0.44 cm3 versus 39.45plusminus5.13 cm3, P <0.00001), HSV-IL2 (20.97plusminus4.60 cm3), and the G207 group (7.71plusminus2.10 cm3). This unique use of a replication-conditional, oncolytic virus to package a replication-incompetent amplicon vector demonstrates impressive efficacy in vitro and in vivo, and avoids the theoretical concerns of recombination with reversion to wild type. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 250~256 | - |
dc.relation.isPartOf | MOLECULAR THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes/immunology | - |
dc.subject.MESH | Carcinoma, Squamous Cell/genetics | - |
dc.subject.MESH | Carcinoma, Squamous Cell/immunology | - |
dc.subject.MESH | Carcinoma, Squamous Cell/pathology | - |
dc.subject.MESH | Carcinoma, Squamous Cell/therapy | - |
dc.subject.MESH | Cell Death | - |
dc.subject.MESH | Cell Division | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunotherapy* | - |
dc.subject.MESH | Interleukin-2/genetics* | - |
dc.subject.MESH | Interleukin-2/immunology* | - |
dc.subject.MESH | Interleukin-2/metabolism | - |
dc.subject.MESH | Interleukin-2/therapeutic use | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Neoplasms/genetics* | - |
dc.subject.MESH | Neoplasms/immunology | - |
dc.subject.MESH | Neoplasms/pathology | - |
dc.subject.MESH | Neoplasms/therapy* | - |
dc.subject.MESH | Simplexvirus/genetics* | - |
dc.subject.MESH | Transfection | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | A Novel Approach to Cancer Therapy Using an Oncolytic Herpes Virus to Package Amplicons Containing Cytokine Genes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학) | - |
dc.contributor.googleauthor | John F. Carew | - |
dc.contributor.googleauthor | David A. Kooby | - |
dc.contributor.googleauthor | Marc W. Halterman | - |
dc.contributor.googleauthor | Se-Heon Kim | - |
dc.contributor.googleauthor | Howard J. Federoff | - |
dc.contributor.googleauthor | Yuman Fong | - |
dc.identifier.doi | 10.1006/mthe.2001.0448 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00605 | - |
dc.relation.journalcode | J02271 | - |
dc.identifier.eissn | 1525-0024 | - |
dc.identifier.pmid | 11545616 | - |
dc.subject.keyword | amplicon | - |
dc.subject.keyword | herpes simplex virus type-1 | - |
dc.subject.keyword | interleukin-2 | - |
dc.subject.keyword | oncolytic virus | - |
dc.contributor.alternativeName | Kim, Se Heon | - |
dc.contributor.affiliatedAuthor | Kim, Se Heon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 4 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 250 | - |
dc.citation.endPage | 256 | - |
dc.identifier.bibliographicCitation | MOLECULAR THERAPY, Vol.4(3) : 250-256, 2001 | - |
dc.identifier.rimsid | 29814 | - |
dc.type.rims | ART | - |
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