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Receptor-Coupled Contractility of Uterine Smooth Muscle: From Membrane to Myofilaments

Authors
 Y.-H. Lee  ;  M.-K. Hwang  ;  K. G. Morgan  ;  Michael J. Taggart 
Citation
 EXPERIMENTAL PHYSIOLOGY, Vol.86(2) : 283-288, 2001 
Journal Title
 EXPERIMENTAL PHYSIOLOGY 
ISSN
 0958-0670 
Issue Date
2001
MeSH
Animals ; Female ; Humans ; Labor, Obstetric/physiology* ; Muscle, Smooth/physiology* ; Pregnancy ; Receptors, Cell Surface/physiology* ; Signal Transduction/physiology ; Uterine Contraction/physiology* ; Uterus/physiology*
Abstract
A comprehensive understanding of the mechanisms by which agonists control uterine contraction is essential for the successful clinical management of parturition and for the timely treatment of situations involving inappropriate uterine performance. In this review we discuss some of the key stimulatory mechanisms linking receptor occupation at the myometrial plasma membrane with alteration of myofilament activation. We focus on evidence that receptor-induced membranous recruitment of the small G-protein rhoA, and its downstream effector rho-associated kinase (ROK) is crucial to agonist-induced Ca2+-sensitisation of uterine contraction and that co-ordination of this signal transduction pathway may be mediated by the actions of caveolins, proteins integral to specialised membranous regions termed caveolae.
Files in This Item:
T200102772.pdf Download
DOI
10.1113/eph8602184
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Young Ho(이영호) ORCID logo https://orcid.org/0000-0002-5749-1045
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142673
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