Cited 9 times in
Comparing the Survival of Two Groups with an Intermediate Clinical Event
DC Field | Value | Language |
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dc.contributor.author | 남정모 | - |
dc.date.accessioned | 2016-02-19T11:13:25Z | - |
dc.date.available | 2016-02-19T11:13:25Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1380-7870 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142669 | - |
dc.description.abstract | Consider a subject entered on a clinicaltrial in which the major endpoint is a time metric such as deathor time to reach a well defined event. During the observationalperiod the subject may experience an intermediate clinical event.The intermediate clinical event may induce a change in the survivaldistribution. We consider models for the one and two sample problem.The model for the one sample problem enables one to test if theoccurrence of the intermediate event changed the survival distribution.This models provides a way of carrying out non-randomized clinicaltrial to determine if a therapy has benefit. The two sample problemconsiders testing if the probability distributions, with andwithout an intermediate event, are the same. Statistical testsare derived using a semi-Markov or a time dependent mixture model.Simulation studies are carried out to compare these new procedureswith the log rank, stratified log rank and landmark tests. Thenew tests appear to have uniformly greater power than these competitortests. The methods are applied to a randomized clinical trialcarried out by the Aids Clinical Trial Group (ACTG) which comparedlow versus high doses of zidovudine (AZT). | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 5~19 | - |
dc.relation.isPartOf | LIFETIME DATA ANALYSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | AIDS-Related Opportunistic Infections/complications | - |
dc.subject.MESH | AIDS-Related Opportunistic Infections/drug therapy | - |
dc.subject.MESH | Acquired Immunodeficiency Syndrome/complications | - |
dc.subject.MESH | Acquired Immunodeficiency Syndrome/drug therapy | - |
dc.subject.MESH | Anti-HIV Agents/administration & dosage | - |
dc.subject.MESH | Anti-HIV Agents/therapeutic use | - |
dc.subject.MESH | Antibiotic Prophylaxis | - |
dc.subject.MESH | Computer Simulation | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | HIV-1 | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Markov Chains | - |
dc.subject.MESH | Models, Statistical* | - |
dc.subject.MESH | Pneumocystis | - |
dc.subject.MESH | Pneumonia, Pneumocystis/complications | - |
dc.subject.MESH | Pneumonia, Pneumocystis/drug therapy | - |
dc.subject.MESH | Randomized Controlled Trials as Topic/methods* | - |
dc.subject.MESH | Survival Analysis* | - |
dc.subject.MESH | Zidovudine/administration & dosage | - |
dc.subject.MESH | Zidovudine/therapeutic use | - |
dc.title | Comparing the Survival of Two Groups with an Intermediate Clinical Event | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학) | - |
dc.contributor.googleauthor | Chung Mo Nam | - |
dc.contributor.googleauthor | Marvin Zelen | - |
dc.identifier.doi | 10.1023/A:1009609925212 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01264 | - |
dc.relation.journalcode | J02168 | - |
dc.identifier.eissn | 1572-9249 | - |
dc.identifier.pmid | 11280847 | - |
dc.identifier.url | http://link.springer.com/article/10.1023/A%3A1009609925212 | - |
dc.subject.keyword | clinical trials | - |
dc.subject.keyword | intermediate events | - |
dc.subject.keyword | semi-Markov processes | - |
dc.subject.keyword | score tests | - |
dc.subject.keyword | zidovudine | - |
dc.contributor.alternativeName | Nam, Jung Mo | - |
dc.contributor.affiliatedAuthor | Nam, Jung Mo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 5 | - |
dc.citation.endPage | 19 | - |
dc.identifier.bibliographicCitation | LIFETIME DATA ANALYSIS, Vol.7(1) : 5-19, 2001 | - |
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