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Effects of diacetyl monoxime and cytochalasin D on ventricular fibrillation in swine right ventricles

Authors
 Moon-Hyoung Lee  ;  Shien-Fong Lin  ;  Toshihiko Ohara  ;  Chikaya Omichi  ;  Yuji Okuyama  ;  Eugene Chudin  ;  Alan Garfinkel  ;  James N. Weiss  ;  Hrayr S. Karagueuzian  ;  Peng-Sheng Chen 
Citation
 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol.280(6) : 2689-2696, 2001 
Journal Title
 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 
ISSN
 0363-6135 
Issue Date
2001
MeSH
Action Potentials/drug effects ; Animals ; Cardiac Pacing, Artificial ; Cytochalasin D/pharmacology* ; Diacetyl/analogs & derivatives* ; Diacetyl/pharmacology* ; Disease Models, Animal ; Electrophysiologic Techniques, Cardiac ; Heart Conduction System/drug effects ; Heart Ventricles/drug effects* ; Heart Ventricles/physiopathology ; In Vitro Techniques ; Optics and Photonics ; Perfusion ; Swine ; Ventricular Dysfunction, Right/drug therapy* ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Fibrillation/drug therapy* ; Ventricular Fibrillation/physiopathology
Abstract
Whether or not the excitation-contraction (E-C) uncoupler diacetyl monoxime (DAM) and cytochalacin D (Cyto D) alter the ventricular fibrillation (VF) activation patterns is unclear. We recorded single cell action potentials and performed optical mapping in isolated perfused swine right ventricles (RV) at different concentrations of DAM and Cyto D. Increasing the concentration of DAM results in progressively shortened action potential duration (APD) measured to 90% repolarization, reduced the slope of the APD restitition curve, decreased Kolmogorov-Sinai entropy, and reduced the number of VF wave fronts. In all RVs, 15-20 mmol/l DAM converted VF to ventricular tachycardia (VT). The VF could be reinduced after the DAM was washed out. In comparison, Cyto D (10-40 micromol/l) has no effects on APD restitution curve or the dynamics of VF. The effects of DAM on VF are associated with a reduced number of wave fronts and dynamic complexities in VF. These results are compatible with the restitution hypothesis of VF and suggest that DAM may be unsuitable as an E-C uncoupler for optical mapping studies of VF in the swine RVs.
Files in This Item:
T200102524.pdf Download
DOI
10.1152/ajpheart.2001.280.6.H2689
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Moon-Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142561
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