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근침윤성 방광암에서 화학방사선 병용을 통한 방광보존치료
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 성진실 | - |
dc.contributor.author | 조재호 | - |
dc.date.accessioned | 2016-02-19T11:08:22Z | - |
dc.date.available | 2016-02-19T11:08:22Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1229-8719 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142483 | - |
dc.description.abstract | Purpose: To determine the long-term results of bladder-preserving approach by transurethral resection of the bladder (TURB), systemic chemotherapy, and radiation therapy for muscle-invasive bladder cancer. Methods and materials: From 1991 Jan. through 1994 Dec., 25 patients with muscle invading clinical stage T2 to T4NxM0 bladder cancer were treated with induction by maximal TURB and (arm 1, n=4) three cycles of chemotherapy [MVAC(methotrexate, vincristine, adriamycin, ciplatin)] followed by 64.8 Gy of radiation with concomitant cisplatin, or two cycles of chemotherapy [MCV (methotrexate, ciplatin, vincristine)] after irradiation with concomitant cisplatin (arm 2, n=14), or concurrent chemoradiation only (arm 3, n=7). Tumor response was scored as a clinical complete response (CR) when the cystoscopic tumor-site biopsy and urine cytology results were negative. Those with less than a CR underwent cystectomy. The median follow-up of all patients was 70 months. Results: Most treatment toxicities were mild to moderate. Grade 3 acute hematologic toxicity and chronic cystitis were observed in only 1 and 2 patients, respectively. Overall 5 year survival was 67.3%. Complete remission rate was 80% (20/25). Sixty-three percent of all survivors retained their bladders. In multivariate analysis, prognostic factors that significantly affect survival were T-stage (p=0.013) and Complete remission (p=0.002). Conclusion: Combined modality therapy with TURB, chemotherapy, and radiation has a 67.3% overall 5 year survival rate. This results is similar to cystectomy-based studies for patients of similar clinical stages. Sixty-three percent of long term survivors preserved their bladders. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 359~368 | - |
dc.language | Korean | - |
dc.publisher | 대한방사선종양학회 | - |
dc.relation.isPartOf | Journal of the Korean Society for Therapeutic Radiology and Oncology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 근침윤성 방광암에서 화학방사선 병용을 통한 방광보존치료 | - |
dc.title.alternative | Bladder Preservation by Combined Modality Therapy for Invasive Bladder Cancer : A Five-Year Follow-up | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | 조재호 | - |
dc.contributor.googleauthor | 임지훈 | - |
dc.contributor.googleauthor | 성진실 | - |
dc.contributor.googleauthor | 표홍렬 | - |
dc.contributor.googleauthor | 금웅섭 | - |
dc.contributor.googleauthor | 서창옥 | - |
dc.contributor.googleauthor | 홍성준 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03901 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A01956 | - |
dc.relation.journalcode | J01857 | - |
dc.subject.keyword | Invasive bladder cancer | - |
dc.subject.keyword | Bladder preservation | - |
dc.subject.keyword | Combined chemoradiotherapy | - |
dc.subject.keyword | Transurethral resection of bladder | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 359 | - |
dc.citation.endPage | 368 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Therapeutic Radiology and Oncology, Vol.19(4) : 359-368, 2001 | - |
dc.identifier.rimsid | 31035 | - |
dc.type.rims | ART | - |
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