갑상선에서 발생한 수질성암-유두상선암종 동시암 1예

Abstract

The simultaneous occurrence of two distinct neoplasms derived from different cells of origin is sometimes recognized. In the thyroid gland, two such distinct tumors could consist of a concurrent medullary carcinoma composed of parafollicular C cells and well-differentiated carcinoma showing follicular epithelial cell differentiation. We report a rare, interesting case of concurrent medullary and papillary carcinoma of the thyroid gland. A 53-year-old female underwent total thyroidectomy and central neck dissection for medullary carcinoma of the left lobe of the thyroid gland, which was diagnosed by fine needle aspiration cytology and a high level of calcitonin. The left lobe showed a medullary carcinoma. the right lobe incidentally showed an papillary microcarcinoma. Two lymph nodes contain metastasis of medullary carcinoma. The two different tumor cells revealed the characteristic features of each on the microscopic, histochemical findings. We report a case of concurrent medullary and papillary carcinoma of the thyroid gland, with a review of the previously reported literature.