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간세포암종 진단에 있어서 자동화 분석기로 측정한 AFP-L3와 PIVKA-Ⅱ의 임상적 유용성
DC Field | Value | Language |
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dc.contributor.author | 백용한 | - |
dc.date.accessioned | 2016-02-19T11:08:08Z | - |
dc.date.available | 2016-02-19T11:08:08Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1226-0479 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142475 | - |
dc.description.abstract | Background / Aims : Prothrombin induced by Vitamin K Antagonist-Ⅱ(PIVKA-Ⅱ)and alpha-fetoprotein(AFP)subtype reacting with Lens Culinaris Agglutinin(AFP-L3)are known as specific tumor markers for HCC. Recently a more sensitive ELA method for PIVKA-Ⅱand an automatic analyzer with Liquid Phase Binding Assay method(LBA method)for AFP-L3 have been developed. The aim of this study was to evaluate the feasibility of PIVKA-Ⅱ and AFP-L3 measured by newly developed methods as complementary tumor markers to AFP in the diagnosis of HCC. Methods : The serum concentration of AFP, PIVKA-Ⅱ, and a fraction of AFP-L3 were determined from 188 patients with HCC and 118 patients with various liver diseases including tumors of the liver. AFP was measured by EIA, PIVKA-Ⅱ by sensitive EIA, and AFP-L3 by the LBA method with LiBASys Auto-analyzer. The cutoff values for AFP, PIVKA-Ⅱ, AND AFP-L3 WERE 400ng/mL, 40 Mau/mL, AND 15%, respectively. Results : The sensitivity and specificity of serum PIVKA-Ⅱwere 69.2% and 76.5%, respectively. Sixty-two(51.2%) of 121 patients with HCC, in which AFP was less than 400ng/mL were PIVKA-Ⅱ positive. The specificity and specificity of serum AFP-L3 were 48.8% and 90.8%, respectively. When AFP-L3 was used in combination with PIVKA-Ⅱ,31(46.3%) of the 67 patients with small less than 3cm HCC were positive for at least one of these markers. Conclusion : PIVKA-Ⅱ measures by sensitive EIA may be useful for the diagnosis of HCC with low AFP level. AFP-L3 and PIVKA-Ⅱ may improve the detection rate of small HCCs less than 3cm. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 467~474 | - |
dc.relation.isPartOf | Korean Journal of Hepatology (대한간학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 간세포암종 진단에 있어서 자동화 분석기로 측정한 AFP-L3와 PIVKA-Ⅱ의 임상적 유용성 | - |
dc.title.alternative | Clinical Implication of Automatically Analysed AFP - L3 and PIVKA - 2 in the Diagnosis of Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | 김철 | - |
dc.contributor.googleauthor | 한광협 | - |
dc.contributor.googleauthor | 백용한 | - |
dc.contributor.googleauthor | 송건훈 | - |
dc.contributor.googleauthor | 정재연 | - |
dc.contributor.googleauthor | 박정엽 | - |
dc.contributor.googleauthor | 박영수 | - |
dc.contributor.googleauthor | 이현웅 | - |
dc.contributor.googleauthor | 전태주 | - |
dc.contributor.googleauthor | 한재용 | - |
dc.contributor.googleauthor | 이관식 | - |
dc.contributor.googleauthor | 전재윤 | - |
dc.contributor.googleauthor | 문영명 | - |
dc.contributor.googleauthor | 이경률 | - |
dc.contributor.googleauthor | 김현숙 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01829 | - |
dc.relation.journalcode | J02036 | - |
dc.subject.keyword | AFP | - |
dc.subject.keyword | PIVKA-II | - |
dc.subject.keyword | AFP-L3 | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | Tumor markers | - |
dc.contributor.alternativeName | Paik, Yong Han | - |
dc.contributor.affiliatedAuthor | Paik, Yong Han | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 7 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 467 | - |
dc.citation.endPage | 474 | - |
dc.identifier.bibliographicCitation | Korean Journal of Hepatology (대한간학회지), Vol.7(4) : 467-474, 2001 | - |
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