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Neonatal intensive care unit outbreak caused by a strain of Klebsiella oxytoca resistant to aztreonam due to overproduction of chromosomal β-lactamase

DC Field Value Language
dc.contributor.author이경원-
dc.date.accessioned2016-02-19T11:07:37Z-
dc.date.available2016-02-19T11:07:37Z-
dc.date.issued2001-
dc.identifier.issn0195-6701-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142455-
dc.description.abstractKlebsiella oxytoca strains resistant to both aztreonam and ceftriaxone were isolated from six neonates in a neonatal intensive care unit and water reservoirs of two humidifiers attached to the neonatal incubators. These isolates were assumed to be of the same clone because they were characterized by the same antimicrobial susceptibility and pulsed field gel electrophoresis patterns. It was established that the drug resistance was attributed to overproduction of chromosomally encoded Kl β-lactamase. It was determined that an isolate (K. oxytoca H1) contained a high enzyme concentration (27mg/100mg of protein in enzyme extracts), at least 27 times higher than the control K. oxytoca N1. It was also demonstrated that isolates had a point mutation in the — 35 concensus region of the promotor gene ofblaOXY-2 leading to enzyme overproduction. Outbreaks caused by K1 hyperproducers have not previously been described.-
dc.description.statementOfResponsibilityopen-
dc.format.extent281~288-
dc.relation.isPartOfJOURNAL OF HOSPITAL INFECTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAztreonam/pharmacology*-
dc.subject.MESHBacterial Proteins*-
dc.subject.MESHCeftriaxone/pharmacology-
dc.subject.MESHCross Infection/epidemiology*-
dc.subject.MESHElectrophoresis, Gel, Pulsed-Field-
dc.subject.MESHHumans-
dc.subject.MESHInfant, Newborn-
dc.subject.MESHIntensive Care Units, Neonatal-
dc.subject.MESHKlebsiella/drug effects*-
dc.subject.MESHKlebsiella/enzymology-
dc.subject.MESHKlebsiella/genetics*-
dc.subject.MESHKlebsiella Infections/epidemiology*-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHPoint Mutation-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHbeta-Lactam Resistance*/genetics-
dc.subject.MESHbeta-Lactamases/genetics-
dc.subject.MESHbeta-Lactamases/metabolism-
dc.titleNeonatal intensive care unit outbreak caused by a strain of Klebsiella oxytoca resistant to aztreonam due to overproduction of chromosomal β-lactamase-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorS.H. Jeong-
dc.contributor.googleauthorW.M. Kim-
dc.contributor.googleauthorC.L. Chang-
dc.contributor.googleauthorJ.M. Kim-
dc.contributor.googleauthorK. Lee-
dc.contributor.googleauthorY. Chong-
dc.contributor.googleauthorH.Y. Hwang-
dc.contributor.googleauthorY.W. Baek-
dc.contributor.googleauthorH.K. Chung-
dc.contributor.googleauthorI.G. Woo-
dc.contributor.googleauthorJ.Y. Ku-
dc.identifier.doi10.1053/jhin.2001.1018-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02649-
dc.relation.journalcodeJ01445-
dc.identifier.eissn1532-2939-
dc.identifier.pmid11461129-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0195670101910187-
dc.subject.keywordKlebsiella oxytoca-
dc.subject.keywordaztreonam-
dc.subject.keywordβ-lactamase (overproduction)-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.rights.accessRightsnot free-
dc.citation.volume48-
dc.citation.number4-
dc.citation.startPage281-
dc.citation.endPage288-
dc.identifier.bibliographicCitationJOURNAL OF HOSPITAL INFECTION, Vol.48(4) : 281-288, 2001-
dc.identifier.rimsid31013-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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