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Cyclooxygenase Inhibitors Regulate the Expression of a TGF-β Superfamily Member That Has Proapoptotic and Antitumorigenic Activities

DC Field Value Language
dc.contributor.author김경수-
dc.date.accessioned2016-02-19T11:07:12Z-
dc.date.available2016-02-19T11:07:12Z-
dc.date.issued2001-
dc.identifier.issn0026-895X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142440-
dc.description.abstractThe antitumorigenic activity of nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase (COX) inhibitors, is well established, but responsible molecular mechanisms are not fully understood. NSAIDs stimulate apoptosis by COX dependent and independent mechanisms in colorectal cells in culture. Identification of genes regulated by COX inhibitors could lead to a better understanding of their proapoptotic and anti-neoplastic activities. Using subtractive hybridization, a cDNA which was designated as NSAID activated gene (NAG-1) was identified from NSAID-treated HCT-116, human colorectal cells. NAG-1 has an identical sequence with a novel member of the TGF-beta superfamily that has 5 different names. In the HCT-116 cells, NAG-1 expression is increased and apoptosis is induced by treatment with some NSAIDs in a concentration and time-dependent manner. NAG-1 transfected cells exhibited increased basal apoptosis, increased response to NSAIDs and reduced soft agar cloning efficiency. Furthermore, transplantable tumors derived from NAG-1 transfected HCT-116 cells showed reduced tumorigenicity in athymic nude mice compared with vector-transfected HCT-116 cells. The increased NAG-1 expression by NSAIDs provides a suitable explanation for COX-independent apoptotic effects of NSAIDs in cultured cells. These data demonstrate that NAG-1 is an antitumorigenic and proapoptotic protein, and its regulation by COX inhibitors may provide new clues for explaining their proapoptotic and antitumorigenic activities.-
dc.description.statementOfResponsibilityopen-
dc.format.extent901~908-
dc.relation.isPartOfMOLECULAR PHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/pharmacology-
dc.subject.MESHAntineoplastic Agents/metabolism-
dc.subject.MESHAntineoplastic Agents/pharmacology*-
dc.subject.MESHApoptosis*-
dc.subject.MESHCell Division/drug effects-
dc.subject.MESHColorectal Neoplasms/metabolism*-
dc.subject.MESHCyclooxygenase Inhibitors/pharmacology*-
dc.subject.MESHCytokines/biosynthesis*-
dc.subject.MESHCytokines/genetics-
dc.subject.MESHCytokines/pharmacology*-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHGene Expression Regulation, Neoplastic/drug effects*-
dc.subject.MESHGrowth Differentiation Factor 15-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHMolecular Sequence Data-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHTransfection-
dc.subject.MESHTransforming Growth Factor beta/genetics-
dc.subject.MESHTumor Cells, Cultured-
dc.subject.MESHTumor Stem Cell Assay-
dc.subject.MESHXenograft Model Antitumor Assays-
dc.titleCyclooxygenase Inhibitors Regulate the Expression of a TGF-β Superfamily Member That Has Proapoptotic and Antitumorigenic Activities-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Otorhinolaryngology (이비인후과학)-
dc.contributor.googleauthorSeung Joon Baek-
dc.contributor.googleauthorKyung-Su Kim-
dc.contributor.googleauthorJennifer B. Nixon-
dc.contributor.googleauthorLeigh C. Wilson-
dc.contributor.googleauthorThomas E. Eling-
dc.identifier.doi10.1124/mol.59.4.901-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00298-
dc.relation.journalcodeJ02267-
dc.identifier.eissn1521-0111-
dc.identifier.pmid11259636-
dc.contributor.alternativeNameKim, Kyung Su-
dc.contributor.affiliatedAuthorKim, Kyung Su-
dc.rights.accessRightsfree-
dc.citation.volume59-
dc.citation.number4-
dc.citation.startPage901-
dc.citation.endPage908-
dc.identifier.bibliographicCitationMOLECULAR PHARMACOLOGY, Vol.59(4) : 901-908, 2001-
dc.identifier.rimsid31004-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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