168 213

Cited 0 times in

Dynamics of Intramural and Transmural Reentry During Ventricular Fibrillation in Isolated Swine Ventricles

DC FieldValueLanguage
dc.contributor.author이문형-
dc.date.accessioned2016-02-19T11:06:51Z-
dc.date.available2016-02-19T11:06:51Z-
dc.date.issued2001-
dc.identifier.issn0009-7330-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142427-
dc.description.abstractThe intramural dynamics of ventricular fibrillation (VF) remain poorly understood. Recent investigations have suggested that stable intramural reentry may underlie the mechanisms of VF. We performed optical mapping studies of VF in isolated swine right ventricles (RVs) and left ventricles (LVs). Nine RV walls were cut obliquely in their distal edge exposing the transmural surface. Six LV wedge preparations were also studied. Results showed that intramural reentry was present. In RV, 28 of 44 VF episodes showed reentry; 15% of the activation pathways were reentrant. Except for 4 episodes, reentry was transmural, involving subendocardial structures as the papillary muscle (PM) or trabeculae. In LV, reentry was observed in 27 of 27 VF episodes; 23% of the activations were part of reentrant pathways (P<0.05 compared with RV). All LV reentrant pathways were truly intramural (confined to the wall) and were frequently located at the PM insertion. In both ventricles, reentry was spatially and temporally unstable. Histological studies showed abrupt changes in fiber orientation at sites of reentry and wave splitting. Connexin 40 immunostaining demonstrated intramyocardial Purkinje fibers at sites of reentry in the PM root and around endocardial trabeculae. Our results confirm that reentry is frequent-but unstable-in the myocardial wall during VF. In RV, reentry is mostly transmural and requires participation of subendocardial structures. The LV has a greater incidence of reentry and is intramural. Anisotropic anatomic structures played key roles in the generation of wave splitting and in the maintenance of reentry.-
dc.description.statementOfResponsibilityopen-
dc.format.extent839~848-
dc.relation.isPartOfCIRCULATION RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAnisotropy-
dc.subject.MESHBody Surface Potential Mapping-
dc.subject.MESHConnexins/metabolism-
dc.subject.MESHElectrophysiologic Techniques, Cardiac-
dc.subject.MESHHeart Conduction System/physiopathology*-
dc.subject.MESHHeart Ventricles/physiopathology*-
dc.subject.MESHIn Vitro Techniques-
dc.subject.MESHMyocardium/metabolism-
dc.subject.MESHOptics and Photonics-
dc.subject.MESHPapillary Muscles/physiopathology-
dc.subject.MESHPurkinje Fibers/metabolism-
dc.subject.MESHSwine-
dc.subject.MESHVentricular Dysfunction, Left/physiopathology-
dc.subject.MESHVentricular Dysfunction, Right/physiopathology-
dc.subject.MESHVentricular Fibrillation/physiopathology*-
dc.titleDynamics of Intramural and Transmural Reentry During Ventricular Fibrillation in Isolated Swine Ventricles-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMiguel Valderrábano-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorToshihiko Ohara-
dc.contributor.googleauthorAngela C. Lai-
dc.contributor.googleauthorMichael C. Fishbein-
dc.contributor.googleauthorShien-Fong Lin-
dc.contributor.googleauthorHrayr S. Karagueuzian-
dc.contributor.googleauthorPeng-Sheng Chen-
dc.identifier.doi10.1161/​hh0801.089259-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02766-
dc.relation.journalcodeJ00535-
dc.identifier.eissn1524-4571-
dc.identifier.pmid11325877-
dc.subject.keywordintramural reentry-
dc.subject.keywordfibrillation-
dc.subject.keywordanisotropy-
dc.subject.keywordpurkinje-
dc.subject.keywordpapillary muscle-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.rights.accessRightsfree-
dc.citation.volume88-
dc.citation.number8-
dc.citation.startPage839-
dc.citation.endPage848-
dc.identifier.bibliographicCitationCIRCULATION RESEARCH, Vol.88(8) : 839-848, 2001-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.