Cited 7 times in
A Feasibility Study Using Three-dimensional Conformal Boost Technique in Locally Advanced Carcinoma of the Nasopharynx
DC Field | Value | Language |
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dc.contributor.author | 김귀언 | - |
dc.contributor.author | 성진실 | - |
dc.contributor.author | 이창걸 | - |
dc.date.accessioned | 2016-02-19T11:05:05Z | - |
dc.date.available | 2016-02-19T11:05:05Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0284-186X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142360 | - |
dc.description.abstract | To investigate the feasibility and efficacy of dose escalation using three-dimensional (3-D) conformal boost technique, 21 patients with stage III or IV nasopharyngeal cancer were enrolled in a prospective protocol. All patients with node metastases initially received external radiotherapy by conventional technique up to 70.2 Gy, followed by 3-D conformal radiotherapy (3-D CRT) to the boost part up to 79.2 Gy with 9 Gy increments (daily fraction of 1.8 Gy for 5 days). A modified technique with the same dose escalation of 9 Gy using 3-D CRT was applied to 7 patients without node metastases, who were treated by conventional technique up to 54 Gy, followed by 3-D CRT to boost up to a basic dose of 70.2 Gy, and then finally with dose escalation of 9 Gy. The protocol was relatively well tolerated by the majority of patients. Acute complications during the dose escalation schedule was low, with rare occurrences of grade 3 or 4 toxicity. Although late radiation-induced complications also appeared limited, 1 patient developed a temporal lobe necrosis and 2 patients suffered from sensory-neural hearing loss. There were no radiation-induced fatal complications. At a median follow-up of 48 months, only 3 patients experienced local failure and 2 patients developed distant metastases. The 5-year overall actuarial survival rate and recurrencefree survival rate for all patients were 68% and 85%, respectively. On the basis of acceptable morbidity and encouraging treatment results, we conclude that the dose escalation in 9 Gy increments using a 3-D conformal boost technique is relatively safe and efficacious, enough to be used routinely for locally advanced nasopharyngeal cancers. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 582~587 | - |
dc.relation.isPartOf | ACTA ONCOLOGICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma/mortality | - |
dc.subject.MESH | Carcinoma/pathology | - |
dc.subject.MESH | Carcinoma/radiotherapy* | - |
dc.subject.MESH | Cavernous Sinus/pathology | - |
dc.subject.MESH | Cranial Nerve Diseases/etiology | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Feasibility Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Hematologic Diseases/etiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Life Tables | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nasopharyngeal Neoplasms/mortality | - |
dc.subject.MESH | Nasopharyngeal Neoplasms/pathology | - |
dc.subject.MESH | Nasopharyngeal Neoplasms/radiotherapy* | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Radiation Injuries/etiology | - |
dc.subject.MESH | Radiodermatitis/etiology | - |
dc.subject.MESH | Radiotherapy Dosage | - |
dc.subject.MESH | Radiotherapy, Conformal/adverse effects | - |
dc.subject.MESH | Radiotherapy, Conformal/methods* | - |
dc.subject.MESH | Skull Base/pathology | - |
dc.subject.MESH | Stomatitis/etiology | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Xerostomia/etiology | - |
dc.title | A Feasibility Study Using Three-dimensional Conformal Boost Technique in Locally Advanced Carcinoma of the Nasopharynx | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Gwi Eon Kim | - |
dc.contributor.googleauthor | Jihoon Lim | - |
dc.contributor.googleauthor | Hee Chul Park | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Sun Rock Moon | - |
dc.contributor.googleauthor | Chang Geol Lee | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.contributor.googleauthor | Chang Ok Suh | - |
dc.identifier.doi | 10.1080/028418601750444114 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00321 | - |
dc.contributor.localId | A01956 | - |
dc.contributor.localId | A03240 | - |
dc.relation.journalcode | J00024 | - |
dc.identifier.eissn | 1651-226X | - |
dc.identifier.pmid | 11669329 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.1080/028418601750444114 | - |
dc.contributor.alternativeName | Kim, Gwi Eon | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Kim, Gwi Eon | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 40 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 582 | - |
dc.citation.endPage | 587 | - |
dc.identifier.bibliographicCitation | ACTA ONCOLOGICA, Vol.40(5) : 582-587, 2001 | - |
dc.identifier.rimsid | 30942 | - |
dc.type.rims | ART | - |
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