Cited 18 times in
Interleukin 6 gene promoter polymorphism is not associated with Kawasaki disease
DC Field | Value | Language |
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dc.contributor.author | 김동수 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 허만욱 | - |
dc.date.accessioned | 2016-02-19T11:03:45Z | - |
dc.date.available | 2016-02-19T11:03:45Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1466-4879 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142310 | - |
dc.description.abstract | We examined the IL-6 gene promoter and detected several interesting promoter polymorphisms: GGGCTG insertion at +162 bp and G deletion at +168 bp positions (M1), A to G substitution at -594 bp (M2) of the reported IL-6 promoter sequence. Other rare variations were also observed at several positions: -583 bp (T insertion), -507 bp (C insertion), -71 bp (T deletion), +17 bp (C insertion), and +121 bp (GC insertion). Although Kawasaki disease (KD) patients demonstrate a drastic increase in serum interleukin-6 (IL-6) during the acute phase that parallels the duration of fever, there were no significant differences in the nucleotide sequence between the KD patients and normal control group. By transient transfection with IL-6 gene promoter-luciferase fusion plasmids into CV-1 cells, we tested the functional significances of the polymorphisms. Mutations at +162 bp, +168 bp and -594 bp significantly decreased luciferase expression (P < 0.05), suggesting the promoter elements flanking the mutated nucleotides are important in transcriptional activation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 357~362 | - |
dc.relation.isPartOf | GENES AND IMMUNITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | DNA Mutational Analysis | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genes, Reporter/genetics | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Interleukin-6/blood | - |
dc.subject.MESH | Interleukin-6/genetics* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mucocutaneous Lymph Node Syndrome/blood | - |
dc.subject.MESH | Mucocutaneous Lymph Node Syndrome/genetics* | - |
dc.subject.MESH | Mutagenesis, Site-Directed | - |
dc.subject.MESH | Mutation/genetics | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Polymorphism, Genetic/genetics* | - |
dc.subject.MESH | Promoter Regions, Genetic/genetics* | - |
dc.subject.MESH | Transcriptional Activation/genetics | - |
dc.subject.MESH | Transfection | - |
dc.title | Interleukin 6 gene promoter polymorphism is not associated with Kawasaki disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | M H Sohn | - |
dc.contributor.googleauthor | M-W Hur | - |
dc.contributor.googleauthor | D S Kim | - |
dc.identifier.doi | 10.1038/sj.gene.6363785 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A04350 | - |
dc.contributor.localId | A00405 | - |
dc.relation.journalcode | J00929 | - |
dc.identifier.eissn | 1476-5470 | - |
dc.identifier.pmid | 11704800 | - |
dc.subject.keyword | Kawasaki disease | - |
dc.subject.keyword | IL-6, promoter | - |
dc.subject.keyword | polymorphism | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Hur, Man Wook | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Hur, Man Wook | - |
dc.contributor.affiliatedAuthor | Kim, Dong Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 2 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 357 | - |
dc.citation.endPage | 362 | - |
dc.identifier.bibliographicCitation | GENES AND IMMUNITY, Vol.2(7) : 357-362, 2001 | - |
dc.identifier.rimsid | 31523 | - |
dc.type.rims | ART | - |
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