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Long-term outcome of kidney transplantation in adult recipients with focal segmental glomerulosclerosis

DC FieldValueLanguage
dc.contributor.author강신욱-
dc.contributor.author김유선-
dc.contributor.author정현주-
dc.contributor.author최규헌-
dc.date.accessioned2016-02-19T11:03:35Z-
dc.date.available2016-02-19T11:03:35Z-
dc.date.issued2001-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142304-
dc.description.abstractFocal segmental glomerulosclerosis (FSGS) is an important cause of nephrotic syndrome and end-stage renal disease. FSGS recurrence after renal transplantation has a potentially detrimental course leading to the loss of renal function. In order to establish FSGS recurrence rates and evaluate the course of the disease on living-related-donor renal transplantation in ethnic Korean adults (≥ 18 years), we reviewed our experiences of 27 kidney transplantations with FSGS over the last 15 years. Of the 27 renal allografts, 13 were found to have recurrent FSGS by graft biopsy. In comparison with background data upon patients with and without recurrence of FSGS, the donor age of patients with recurrent FSGS was significantly higher than that of those without recurrence (median, 39 years vs 26, p < 0.05). In terms of, age at transplantation, length of dialysis period, and mode of dialysis no differences were found between recurrent and nonrecurrent cases. The graft survival rate of recipients from a kidney donor of age less than 40 years was significantly higher than that of recipients from a kidney donor of age more than 40 years, at 5 and 10 years, respectively (87% vs 33%, 41% vs 0%, p < 0.05). The association between clinical variables and recurrence was assessed by multiple logistic regression analysis, and donor age was found to be a risk factor of FSGS recurrence (p <0.05). Variables such as HLA-mismatch numbers and immunosuppression were not found to be associated. In conclusion, the recurrence rate of FSGS in adult recipients with FSGS was 48% and patients that received kidney from an older donor appear to be at higher risk of developing recurrence. The use of a renal graft from a younger donor is considered advisable for adult recipients with FSGS.-
dc.description.statementOfResponsibilityopen-
dc.format.extent209~214-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGlomerulosclerosis, Focal Segmental/surgery*-
dc.subject.MESHHumans-
dc.subject.MESHKidney Transplantation*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHRecurrence-
dc.subject.MESHTreatment Outcome-
dc.titleLong-term outcome of kidney transplantation in adult recipients with focal segmental glomerulosclerosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorSoo Young Yoon-
dc.contributor.googleauthorJae Hun Kim-
dc.contributor.googleauthorShin Wook Kang-
dc.contributor.googleauthorSung Kyu Ha-
dc.contributor.googleauthorHo Yung Lee-
dc.contributor.googleauthorDae Suk Han-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorKiil Park-
dc.contributor.googleauthorHyeon Joo Jeong-
dc.contributor.googleauthorDong Kee Kim-
dc.identifier.doi10.3349/ymj.2001.42.2.209-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00053-
dc.contributor.localIdA00785-
dc.contributor.localIdA03771-
dc.contributor.localIdA04043-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid11371109-
dc.subject.keywordFocal segmental glomerulosclerosis-
dc.subject.keywordrenal transplantation-
dc.subject.keywordrecurrence-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameJeong, Hyeon Joo-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorJeong, Hyeon Joo-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.rights.accessRightsfree-
dc.citation.volume42-
dc.citation.number2-
dc.citation.startPage209-
dc.citation.endPage214-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.42(2) : 209-214, 2001-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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