Cited 186 times in
Nerve Sprouting and Sympathetic Hyperinnervation in a Canine Model of Atrial Fibrillation Produced by Prolonged Right Atrial Pacing
DC Field | Value | Language |
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dc.contributor.author | 이문형 | - |
dc.date.accessioned | 2016-02-19T10:59:29Z | - |
dc.date.available | 2016-02-19T10:59:29Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0009-7322 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142148 | - |
dc.description.abstract | BACKGROUND: Long-term rapid atrial pacing may result in atrial fibrillation (AF) in dogs. Whether there is histological evidence for neural remodeling is unclear. METHOD AND RESULTS: We performed rapid right atrial pacing in 6 dogs for 111+/-76 days to induce sustained AF. Tissues from 6 healthy dogs were used as controls. Immunocytochemical staining of cardiac nerves was performed using anti-growth-associated protein 43 (GAP43) and anti-tyrosine hydroxylase (TH) antibodies. In dogs with AF, the density of GAP43-positive and TH-positive nerves in the right atrium was 470+/-406 and 231+/-126 per mm(2), respectively, which was significantly (P:<0.001) higher than the nerve density in control tissues (25+/-32 and 88+/-40 per mm(2), respectively). The density of GAP43-positive and TH-positive nerves in the atrial septum was 317+/-36 and 155+/-85 per mm(2), respectively, and was significantly (P:<0.001) higher than the nerve density in control tissues (9+/-13 and 30+/-7 per mm(2), respectively). Similarly, the density of GAP43-positive and TH-positive nerves in the left atrium of dogs with AF was 119+/-61 and 91+/-40 per mm(2), respectively, which was significantly (P:<0.001) higher than the nerve density in control tissues (10+/-15 and 38+/-39 per mm(2), respectively). Furthermore, in dogs with AF, the right atrium had a significantly higher nerve density than the left atrium. Microscopic examinations revealed an inhomogeneous distribution of cardiac nerves within each sampling site. CONCLUSIONS: Significant nerve sprouting and sympathetic hyperinnervation are present in a canine model of sustained AF produced by prolonged right atrial pacing. The magnitude of nerve sprouting and hyperinnervation was higher in the right atrium than in the left atrium. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 22~25 | - |
dc.relation.isPartOf | CIRCULATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Atrial Fibrillation/pathology* | - |
dc.subject.MESH | Cardiac Pacing, Artificial | - |
dc.subject.MESH | Cell Count | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart/innervation* | - |
dc.subject.MESH | Heart Atria/pathology | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Myocardium/pathology* | - |
dc.subject.MESH | Neurons/pathology* | - |
dc.subject.MESH | Sympathetic Nervous System/pathology* | - |
dc.title | Nerve Sprouting and Sympathetic Hyperinnervation in a Canine Model of Atrial Fibrillation Produced by Prolonged Right Atrial Pacing | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Che-Ming Chang | - |
dc.contributor.googleauthor | Tsu-Juey Wu | - |
dc.contributor.googleauthor | Shengmei Zhou | - |
dc.contributor.googleauthor | Rahul N. Doshi | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Toshihiko Ohara | - |
dc.contributor.googleauthor | Michael C. Fishbein | - |
dc.contributor.googleauthor | Hrayr S. Karagueuzian | - |
dc.contributor.googleauthor | Peng-Sheng Chen | - |
dc.contributor.googleauthor | Lan S. Chen | - |
dc.identifier.doi | 10.1161/01.CIR.103.1.22 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02766 | - |
dc.relation.journalcode | J00533 | - |
dc.identifier.eissn | 1524-4539 | - |
dc.identifier.pmid | 11136680 | - |
dc.subject.keyword | remodeling | - |
dc.subject.keyword | electrophysiology | - |
dc.subject.keyword | nervous system, autonomic | - |
dc.subject.keyword | tachyarrhythmias | - |
dc.subject.keyword | catecholamines | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 103 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 22 | - |
dc.citation.endPage | 25 | - |
dc.identifier.bibliographicCitation | CIRCULATION, Vol.103(1) : 22-25, 2001 | - |
dc.identifier.rimsid | 31639 | - |
dc.type.rims | ART | - |
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