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고콜레스테롤혈증 환자에서 식물성 스테롤이 혈청 지질농도에 미치는 영향

Other Titles
 The Effect of Plant Sterol on Serum Cholesterol in Hypercholesterolemia Patients 
Authors
 신민정 ; 임세중 ; 정남식 ; 송기준 ; 김동기 ; 김성순 ; 조승연 ; 강석민 ; 최동훈 ; 장양수 
Citation
 Korean Circulation Journal (순환기), Vol.31(10) : 1027~1033, 2001 
Journal Title
 Korean Circulation Journal  (순환기) 
ISSN
 1738-5520 
Issue Date
2001
Abstract
Background and Objectives : Phytosterols(Plant sterols) have been known to reduce serum cholesterol concentrations by inhibiting the absorption of both dietary and biliary cholesterol from the small intestines. In consideration of the lack of evaluation in Korea into the hypercholesterolemic effect of plant sterols, this study investigated the effect of plant sterol containing beverage on blood lipid profiles in hypercholesterolemic patients. Materials and Methods : Forty-five hypercholesterolemic patients(fasting LDL-cholesterol>130 mg/dL) were fed either a placebo beverage for 4 weeks or a test beverage containing plant sterols for 8 weeks in a single-blind, randomized, cross-over study. The subjects were instructed to maintain the same amount of dietary fat and cholesterol intake during the study. After 4 weeks of plant sterols treatment, the dose of plant sterols was doubled (3.2 g/d) for subjects whose LDL-cholesterol reduction rate had not been reduced by 15%. Results : The study population consisted 45 patients(15 males, 30 females, mean age 56) who completed the whole protocol. At baseline, the subjects' mean dietary intake of saturated fat was 11.12 g, and cholesterol was 135.2 mg. After 8 weeks treatment with plant sterols, serum concentrations of total cholesterol and LDL-cholesterol were significantly reduced by 4.38%(p= 0.039), and 8.28%(p=0.036), respectively. However, the HDL-cholesterol and triglyceride levels/concentrations did not change significantly. Two-thirds of the subjects responded to treatment with plant sterols, and the mean reduction rates in LDL-cholesterol and total cholesterol levels/concentrations of those subjects were 14.1% and 9.2% respectively. Conclusion : Our findings indicate that plant sterols significantly reduce serum total cholesterol and LDL-cholesterol concentrations and further suggest that plant sterols are also effective for those with low cholesterol intake.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142113
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Yonsei Cardiovascular Research Institute
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Biostatistics
Yonsei Authors
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