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폐경 후 호르몬 보충요법중인 여성에게 병합 투여된 Alendronate 의 효과
DC Field | Value | Language |
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dc.contributor.author | 배상욱 | - |
dc.contributor.author | 이병석 | - |
dc.date.accessioned | 2016-02-19T10:56:46Z | - |
dc.date.available | 2016-02-19T10:56:46Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1226-8704 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142050 | - |
dc.description.abstract | Objective: This study was designed for determination of the additional effect of alendronate to ongoing hormone replacement therapy in postmenopausal women. Methods: Alendronate (10mg/day, orally) was added in 66 postmenopausal women with estrogen replacement therapy who were taken HRT more than 2 years previously. The patients were followed up for 1 year thereafter. We measured bone mineral density and bone turnover markers (osteocalcin, ALP, D-Pyridinoline/Cr) at that time prior to HRT, 1 year, 2 year after HRT and 1 year after combination of alendronate therapy. Results : The BMD(g/㎠) of L2-4 were 1.09±2.44(T-score -2.86±0.69) prior to HRT, 0.82±0.07(T-score -2.53±0.49) 1yr after HRT, 0.80±0.11(T-score -2.61±0.92) 2yr after HRT, and 0.88±0.08(T-score -2.05±0.70) after combination therapy. Serum osteocalcin(ng/ml) level were 30.3±14.8, 21.09±14.09, 17.31±8.46, and 10.85±9.09 respectively. Dpd/Cr(nmole/mmole) were 7.0±4.5, 5.82±0.91, 5.29±2.15, and 4.22±0.61. From these results, we can observe more significant increase of BMD and decrease of bone turnover rate following combined therapy rather than HRT only. Conclusion: This study shows that the addition of alendronate is beneficial in postmenopausal women with ongoing estrogen replacement therapy by preventing or treatment of osteoporosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 134~142 | - |
dc.relation.isPartOf | Journal of Korean Society of Menopause (대한폐경학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 폐경 후 호르몬 보충요법중인 여성에게 병합 투여된 Alendronate 의 효과 | - |
dc.title.alternative | The Effect of Additional Alendronate to ongoing Hormone Replacement Therapy in Postmenopausal Women | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology (산부인과학) | - |
dc.contributor.googleauthor | 안은희 | - |
dc.contributor.googleauthor | 정경아 | - |
dc.contributor.googleauthor | 김정연 | - |
dc.contributor.googleauthor | 배상욱 | - |
dc.contributor.googleauthor | 이병석 | - |
dc.contributor.googleauthor | 박기현 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01793 | - |
dc.contributor.localId | A02795 | - |
dc.relation.journalcode | J01546 | - |
dc.subject.keyword | HRT | - |
dc.subject.keyword | Alendronate | - |
dc.subject.keyword | BMD | - |
dc.subject.keyword | bone turnover markers | - |
dc.subject.keyword | osteoporosis | - |
dc.contributor.alternativeName | Bai, Sang Wook | - |
dc.contributor.alternativeName | Lee, Byung Seok | - |
dc.contributor.affiliatedAuthor | Bai, Sang Wook | - |
dc.contributor.affiliatedAuthor | Lee, Byung Seok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 7 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 134 | - |
dc.citation.endPage | 142 | - |
dc.identifier.bibliographicCitation | Journal of Korean Society of Menopause (대한폐경학회지), Vol.7(2) : 134-142, 2001 | - |
dc.identifier.rimsid | 31561 | - |
dc.type.rims | ART | - |
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