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간성 뇌증의 치료로서 Rifaximin ( Normix ) 단기간 투여의 효능과 안전성

Other Titles
 Efficacy and Safety of Short-term Administration of Rifaximin in the Treatment of Hepatic Encephalopathy 
Authors
 김명환  ;  한광협  ;  이관식  ;  백용한  ;  송건훈  ;  나호균  ;  문병수  ;  윤석화  ;  전재윤  ;  문영명  ;  박인서 
Citation
 Korean Journal of Hepatology (대한간학회지), Vol.7(1) : 55-60, 2001 
Journal Title
 Korean Journal of Hepatology (대한간학회지) 
ISSN
 1226-0479 
Issue Date
2001
Keywords
Rifaximin ; Hepatic encephalopathy
Abstract
Background/Aims: A prospective, randomized study was performed to evaluate the efficacy and safety of the short-term administration of rifaximin in the treatment of hepatic encephalopathy. Methods: Of the 64 patients diagnosed as having decompensated liver cirrhosis with hepatic encephalopathy, 39 patients were randomized to receive rifaximin and 25 patients to receive lactulose for seven days. Before and after the treatment we assessed changes in the level of serum ammonia, flapping tremor, patient's mental status, number connection test (NCT), and hepatic encephalopathy indices. Results: In rifaximin-treated group, the mean grade of serum ammonia (1.8→0.9), mental status (1.3→0.3), NCT (3.0→2.0), and flapping tremor (1.7→0.4) were improved after treatment. In the lactulose-treated group, the mean grade of serum ammonia (1.9→1.0), mental status (1.5→0.5), NCT (3.3→2.1), and flapping tremor (1.4→0.3) were improved after treatment. Side effects of abdominal pain (rifaximin group) and excessive diarrhea (lactulose group) were noted in 2 cases. The efficacy of treatment was not significantly different between rifaximin and lactulose-treated groups (84.3% vs. 95.3%). Conclusion: Rifaximin was as efficient and safe in the treatment of hepatic encephalopathy as lactulose in terms of efficacy. Rifaximin may be useful drug for the short-term treatment of hepatic encephalopathy
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Paik, Yong Han(백용한)
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142006
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