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In Vitro Activities of 2,2'-Dipyridyl Against Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis
DC Field | Value | Language |
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dc.contributor.author | 신명헌 | - |
dc.date.accessioned | 2016-02-19T10:55:05Z | - |
dc.date.available | 2016-02-19T10:55:05Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141988 | - |
dc.description.abstract | The in vitro activity of 2,2´-dipyridyl, an ironchelator, against clinical isolates of Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis was evaluated and compared with those of four other vaginal suppositories, ornidazole, clotrimazole, povidone-iodine, and Cenacert^ (Methylbenzethonium Chloride mixed with 9-aminoacrydine undecylenate and hydrochloric acid N-myristyl-3-hydroxy butyl amine). The 2,2´-dipyridyl killed T. vaginalis and G. vaginalis at concentrations of 410㎍/ml and 205㎍/ml, respectively, however, this agent was less active against C. albicans (80% of which was inhibited at 410㎍/ml). The inhibition of these three pathogens by 2,2´-dipyridyl was similar to clotrimazole. In addition, the effect of 2,2´-dipyridyl on the ultrastructure of T. vaginalis, C. albicans, and G. vaginalis was examined. Transmission electron microscopy indicated that 2,2´-dipyridyl induced modifications of the cellular contents and cell envelope concomitant with the degradation of the three pathogens. These results suggest that 2,2´-dipyridyl has an inhibitory effect on C. albicans and G. vaginalis, as well as T. vaginalis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 124~130 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | In Vitro Activities of 2,2'-Dipyridyl Against Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Ryu Jae Sook | - |
dc.contributor.googleauthor | Min Duk Young | - |
dc.contributor.googleauthor | Kim Myeong Cheol | - |
dc.contributor.googleauthor | Kim Nam Sik | - |
dc.contributor.googleauthor | Shin Myeong Heon | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02099 | - |
dc.relation.journalcode | J01594 | - |
dc.identifier.eissn | 1738-8872 | - |
dc.subject.keyword | 2,2'-dipyridyl | - |
dc.subject.keyword | Trichomonas vaginalis | - |
dc.subject.keyword | candida albicans | - |
dc.subject.keyword | gardnerella vaginalis | - |
dc.contributor.alternativeName | Shin, Myeong Heon | - |
dc.contributor.affiliatedAuthor | Shin, Myeong Heon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 124 | - |
dc.citation.endPage | 130 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, Vol.11(1) : 124-130, 2001 | - |
dc.identifier.rimsid | 35907 | - |
dc.type.rims | ART | - |
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