Cited 53 times in
Oxidative Stress and Neuronal DNA Fragmentation Mediate Age-Dependent Vulnerability to the Mitochondrial Toxin, 3-Nitropropionic Acid, in the Mouse Striatum
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2016-02-19T10:54:51Z | - |
dc.date.available | 2016-02-19T10:54:51Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0969-9961 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141979 | - |
dc.description.abstract | Oxidative stress is involved in the neuropathology of several neurodegenerative diseases and stroke, all of which are related to excitotoxicity. Age-dependent vulnerability is characteristic of these conditions. It is not clear whether apoptosis-related neuronal death is involved in age-dependent vulnerability to excitotoxicity. We evaluated whether apoptosis-related neuronal death after treatment with 3-nitropropionic acid (3-NP) is age-dependent in the mouse striatum. We have demonstrated that oxidative stress occurs early after 3-NP treatment and even more so in aged mice. DNA fragmentation with terminal deoxynucleotidyl transferase-mediated uridine 5′-triphosphate-biotin nick end labeling staining and gel electrophoresis occurred in an age-dependent fashion. Expression of the DNA repair enzyme, apurinic/apyrimidinic endonuclease, was more attenuated in old mice. Therefore, these results suggest that oxidative stress induces age-dependent neuronal apoptosis in the mouse striatum after 3-NP treatment, which in turn produces an age-dependent vulnerability to 3-NP. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 114~126 | - |
dc.relation.isPartOf | NEUROBIOLOGY OF DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aging/physiology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Cytochrome c Group/metabolism | - |
dc.subject.MESH | DNA Fragmentation/drug effects* | - |
dc.subject.MESH | Electrophoresis, Polyacrylamide Gel | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mitochondria/drug effects* | - |
dc.subject.MESH | Neostriatum/drug effects | - |
dc.subject.MESH | Neostriatum/growth & development | - |
dc.subject.MESH | Neostriatum/metabolism* | - |
dc.subject.MESH | Neurons/drug effects | - |
dc.subject.MESH | Neurons/metabolism* | - |
dc.subject.MESH | Neurotoxins/toxicity* | - |
dc.subject.MESH | Nitro Compounds | - |
dc.subject.MESH | Nuclear Proteins/metabolism | - |
dc.subject.MESH | Oxidative Stress/drug effects* | - |
dc.subject.MESH | Propionates/toxicity* | - |
dc.title | Oxidative Stress and Neuronal DNA Fragmentation Mediate Age-Dependent Vulnerability to the Mitochondrial Toxin, 3-Nitropropionic Acid, in the Mouse Striatum | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Gyung W. Kim | - |
dc.contributor.googleauthor | Pak H. Chan | - |
dc.identifier.doi | 10.1006/nbdi.2000.0327 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00310 | - |
dc.relation.journalcode | J02323 | - |
dc.identifier.eissn | 1095-953X | - |
dc.identifier.pmid | 11162245 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0969996100903279 | - |
dc.contributor.alternativeName | Kim, Gyung Whan | - |
dc.contributor.affiliatedAuthor | Kim, Gyung Whan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 114 | - |
dc.citation.endPage | 126 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF DISEASE, Vol.8(1) : 114-126, 2001 | - |
dc.identifier.rimsid | 35898 | - |
dc.type.rims | ART | - |
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