백서에서 MgSO4와 Bupivacaine의 지주막하 병용투여에 의해 강화된 진통효과

Abstract

Background: Based on previously reported articles, magnesium sulphate seemed to cause a motor paralysis, but not complete analgesia when administered intrathecally alone, but is likely to have a partial analgesic effect. Accordingly, we tested a hypothesis that magnesium sulphate might potentiate the analgesic effect when coadministered intrathecally with bupivacaine. Methods: Eighteen male Sprague-Dawley rats were allocated into three groups of six animals each. The duration of sensory blockade was determined by observing the period when the animal did not vocalize and/or withdraw (struggle) while forceps-pinch tests were applied to a hindlimb paw. The six animals in each of the following three groups were injected intrathecally with 0.03㎖ of the different test substances: (group 1) 16.7% magnesium sulphate {50% magnesium sulphate (0.01㎖) + 0.9% sodium chloride (0.02㎖)}; (group 2) 50% magnesium sulphate (0.01㎖) + 0.5% bupivacaine (0.02㎖); (group 3) 0.33% bupivacaine {0.5% bupivacaine (0.02㎖) + 0.9% sodium chloride (0.01㎖)}. Results: Sensory blockade in the hindlimbs was observed only in group 2 and lasted for 12 to 14 minutes, while there were no sensory blockades in group 1 and group 3. Conclusions: Magnesium sulphate potentiated the analgesic effect of bupivacaine when coadm inistered intrathecally with bupivacaine in rats. These results suggest that intrathecal administration of magnesium sulphate may be a useful adjunct to spinal bupivacaine anesthesia.