Cited 2 times in
Effect of apolipoprotein E polymorphism on the serum lipid and insulin response to whole grain consumption in coronary artery disease patients
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2016-02-19T10:53:08Z | - |
dc.date.available | 2016-02-19T10:53:08Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141918 | - |
dc.description.abstract | Whether apo E polymorphism influenced serum lipids and insulin response to the isocalorical replacement of refined rice with whole grains was investigated in coronary artery disease (CAD) men with a low-fat diet. CAD men (n=110) were switched from their basal diet (61% carbohydrate and 19% fat) to isoenergetic diet containing 70g whole grain powder (220kcal), as a carbohydrate source of breakfast for 16 weeks. Apo E2 group (n=11) showed higher baseline serum triglyceride than apo E3 group (n=82). Baseline serum concentrations of total and LDL cholesterol and apo B were highest in apo E4 group (n=16), intermediate in apo E3 and lowest in apo E2. Apo E3 groups showed significantly decreases of triglyceride, total and LDL cholesterol and apo B by 12%, 5%, 8% and 8% after 16 weeks, respectively. In apo E4 group, similar decrease of LDL cholesterol and apo B was observed. HDL cholesterol significantly increased by 8% and 15% in apo E3 and E4 groups, respectively. Apo E3 group showed about 9% decrease in fasting insulin and glucose. Apo E genotype modified the serum lipids and insulin response to the isocalorical replacement of refined rice with whole grains in CAD men with a low-fat diet; apo E2 subjects were non-responders, while apo E3 subjects were favorable responders. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1463~1473 | - |
dc.relation.isPartOf | NUTRITION RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of apolipoprotein E polymorphism on the serum lipid and insulin response to whole grain consumption in coronary artery disease patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Hyun Young Park | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.contributor.googleauthor | Ji Sun Ham | - |
dc.contributor.googleauthor | Ha Jung Ryu | - |
dc.identifier.doi | 10.1016/S0271-5317(01)00384-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J02401 | - |
dc.identifier.eissn | 1879-0739 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0271531701003840 | - |
dc.subject.keyword | Apolipoprotein E | - |
dc.subject.keyword | Polymrphism | - |
dc.subject.keyword | Whole grain | - |
dc.subject.keyword | Insulin | - |
dc.subject.keyword | Cholesterol | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1463 | - |
dc.citation.endPage | 1473 | - |
dc.identifier.bibliographicCitation | NUTRITION RESEARCH, Vol.21(12) : 1463-1473, 2001 | - |
dc.identifier.rimsid | 35854 | - |
dc.type.rims | ART | - |
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