1299 766

Cited 0 times in

간경변 환자의 영양상태에 있어서 경구용 분지형 아미노산 제제의 효과에 대한 전향적 연구

Other Titles
 Prospective Study on Efficacy of Oral Supplement of Branched - Chain Amino Acid Granules on the Nutritional Status of the Cirrhotics 
 송건훈  ;  김명수  ;  한광협  ;  이관식  ;  전재윤  ;  문영명  ;  안수현  ;  이종호 
 Korean Journal of Hepatology (대한간학회지), Vol.7(4) : 432-438, 2001 
Journal Title
Korean Journal of Hepatology(대한간학회지)
Issue Date
Oral supplement ; Branched- chain amino acid ; Liver cirrhosis
Background / Aims : A prospective comparative study was conducted to investigate the efficacy of orally administered branched-chain amino acids(BCAA) in cirrhotic patients. Methods : Forty-seven patients with liver cirrhosis of viral etiologies, whose hypoalbunemia could not be corrected with adequate protein intake, were randomly assigned to either the BCAA group(n=31) or the control group(n=16). The selection criteria were ages between 16 and 70 years, patients whose Child-Pugh scores were less than 13 points and who were willing to participate in the study. Most patients(87.1%) belonged to Child -Pugh class B. Patients in the BCAA group received oral supplementation with branced-chain amino acid granules(12g/day, each packet containing total 4g of BCAA , i.e.leucine, 1904 mg ; valine, 1144mg; isoleucine, 952mg) for 12 weeks. Patients had complete blood counts and chemistry at entry and once every month. Serum ferritin and amino acid concentrations in plasma were determined. Anthropometric parameters including body weight, body fat contents and body mass index were assessed at the beginning and at the end of the 3-month period. Results : In the BCAA group, there was a significant increment in plasma levels of isoleucine, valine(p<0.001) whereas levels of aromatic amino acids did not show substantial change. Total BCAA concentration and BCAA/AAA(aromatic amino acid) molar ratio(Fischer`s ratio) also increased significantly after administration of oral BCAA (p<0.02). In contrast, patients in the control group showed no significant change in assessed parameters. Conclusion : Oral supplementation of BCAA to or other serious adverse effects.
Files in This Item:
T200100065.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.