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Recurrence Risk-Scoring Model for Stage I Adenocarcinoma of the Lung

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dc.contributor.author정경영-
dc.date.accessioned2016-02-04T12:03:29Z-
dc.date.available2016-02-04T12:03:29Z-
dc.date.issued2015-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141796-
dc.description.abstractPURPOSE: The aim of this retrospective, multicenter study was to develop a recurrence risk-scoring model in patients with curatively resected stage I lung adenocarcinoma (ADC). METHODS: Clinicopathologic and outcome data for a development cohort of 1,700 patients with pathologic stage I ADC from four institutions resected between January 2000 and December 2009 were evaluated. A phantom study was performed for correction of inter-institutional differences in positron emission tomography-standardized uptake value (PET-SUV). A nomogram for recurrence prediction was developed using Cox proportional hazards regression. This model was validated in a cohort of 460 patients in two other hospitals. The recurrence rate was 21.0 % for the development cohort and 22.1 % for the validation cohort. RESULTS: In multivariable analysis, three independent predictors for recurrence were identified: pathologic tumor size (hazard ratio [HR] 1.03, 95 % CI 1.017-1.048; p < 0.001), corrected PET-SUV (HR 1.08, 95 % CI 1.051-1.105; p < 0.001), and lymphovascular invasion (HR 1.65, 95 % CI 1.17-2.33; p = 0.004). The nomogram was made based on these factors and a calculated risk score was accorded to each patient. Kaplan-Meier analysis of the development cohort showed a 5-year recurrence-free survival (RFS) of 83 % (95 % CI 0.80-0.86) in low-risk patients and 59 % (95 % CI 0.54-0.66) in high-risk patients with the highest 30 percentile scores. The concordance index was 0.632 by external validation. CONCLUSIONS: This recurrence risk-scoring model can be used to predict the RFS for pathologic stage I ADC patients using the above three easily measurable factors. High-risk patients need close follow-up and can be candidates for adjuvant chemotherapy.-
dc.description.statementOfResponsibilityopen-
dc.format.extent4089~4097-
dc.relation.isPartOfAnnals of Surgical Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRecurrence Risk-Scoring Model for Stage I Adenocarcinoma of the Lung-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthorHee Chul Yang-
dc.contributor.googleauthorHyeong Ryul Kim-
dc.contributor.googleauthorJae Yong Park-
dc.contributor.googleauthorJu Sik Yun-
dc.contributor.googleauthorKook Joo Na-
dc.contributor.googleauthorYoung Mog Shim-
dc.contributor.googleauthorJhingook Kim-
dc.contributor.googleauthorJong Mog Lee-
dc.contributor.googleauthorMoon Soo Kim-
dc.contributor.googleauthorJae Ill Zo-
dc.contributor.googleauthorSe Hoon Choi-
dc.contributor.googleauthorDong Kwan Kim-
dc.contributor.googleauthorSeong Yong Park-
dc.contributor.googleauthorMi Kyung Bae-
dc.contributor.googleauthorKyung Young Chung-
dc.contributor.googleauthorJin-Haeng Chung-
dc.contributor.googleauthorHo-Young Lee-
dc.contributor.googleauthorSoyeon Ahn-
dc.contributor.googleauthorSukki Cho-
dc.contributor.googleauthorKwhanmien Kim-
dc.contributor.googleauthorSanghoon Jheon-
dc.identifier.doi10.1245/s10434-015-4411-9-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03571-
dc.relation.journalcodeJ00179-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-015-4411-9-
dc.contributor.alternativeNameChung, Kyung Young-
dc.contributor.affiliatedAuthorChung, Kyung Young-
dc.rights.accessRightsnot free-
dc.citation.volume22-
dc.citation.number12-
dc.citation.startPage4089-
dc.citation.endPage4097-
dc.identifier.bibliographicCitationAnnals of Surgical Oncology, Vol.22(12) : 4089-4097, 2015-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)

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