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Serum leucine-rich α2-glycoprotein is a useful biomarker for monitoring disease activity in patients with adult-onset Still's disease

DC FieldValueLanguage
dc.contributor.author박용범-
dc.contributor.author이수곤-
dc.date.accessioned2016-02-04T12:02:42Z-
dc.date.available2016-02-04T12:02:42Z-
dc.date.issued2015-
dc.identifier.issn0300-9742-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141766-
dc.description.abstractOBJECTIVE: To investigate whether serum leucine-rich α2-glycoprotein (LRG) levels are elevated in patients with adult-onset Still's disease (AOSD) and determine their correlation with disease activity parameters. METHOD: We enrolled 39 patients with AOSD, 47 patients with rheumatoid arthritis (RA), and 39 controls. Forty-five serum samples from the patients with AOSD were assayed for LRG using an enzyme-linked immunosorbent assay (ELISA). Comprehensive AOSD activity was determined by a modified Pouchot score. RESULTS: Serum LRG levels were significantly elevated in patients with AOSD (128.8 ± 40.8 ng/mL) compared to those in patients with RA and in controls (33.9 ± 15.2 ng/mL, p < 0.001 and 22.4 ± 6.1 ng/mL, p < 0.001, respectively). Patients with active AOSD had significantly higher LRG levels than those with inactive disease (141.4 ± 31.3 ng/mL vs. 79.8 ± 37.1 ng/mL, p = 0.002). Serum LRG levels were positively correlated with C-reactive protein (CRP; γ = 0.387, p = 0.015), lactate dehydrogenase (LDH; γ = 0.370, p = 0.026), ferritin (γ = 0.687, p < 0.001) levels, and the modified Pouchot score (γ = 0.756, p < 0.001). Serum LRG levels decreased significantly after treatment in all six patients with active AOSD who had follow-up evaluations (p = 0.007). The best cut-off value for LRG to distinguish AOSD from RA was 67.9 ng/mL, with a sensitivity of 92.3% and a specificity of 97.9%. CONCLUSIONS: Serum LRG levels were increased in patients with AOSD and correlated well with disease activity measures. LRG may be a useful biomarker for distinguishing AOSD from RA and for monitoring the disease activity of AOSD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent399~403-
dc.relation.isPartOfSCANDINAVIAN JOURNAL OF RHEUMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHC-Reactive Protein/metabolism-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHDisease Progression*-
dc.subject.MESHFemale-
dc.subject.MESHFerritins/blood-
dc.subject.MESHGlycoproteins/blood*-
dc.subject.MESHHumans-
dc.subject.MESHL-Lactate Dehydrogenase/blood-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSeverity of Illness Index*-
dc.subject.MESHStill's Disease, Adult-Onset/blood-
dc.subject.MESHStill's Disease, Adult-Onset/diagnosis*-
dc.titleSerum leucine-rich α2-glycoprotein is a useful biomarker for monitoring disease activity in patients with adult-onset Still's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorY-J Ha-
dc.contributor.googleauthorE-J Kang-
dc.contributor.googleauthorS-W Lee-
dc.contributor.googleauthorY-B Park-
dc.contributor.googleauthorS-K Lee-
dc.contributor.googleauthorJ-S Song-
dc.contributor.googleauthorST Choi-
dc.identifier.doi10.3109/03009742.2015.1016103-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01579-
dc.contributor.localIdA02889-
dc.relation.journalcodeJ02635-
dc.identifier.eissn1502-7732-
dc.identifier.pmid26079682-
dc.identifier.urlhttp://www.tandfonline.com/doi/abs/10.3109/03009742.2015.1016103-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameLee, Soo Kon-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorLee, Soo Kon-
dc.rights.accessRightsnot free-
dc.citation.volume44-
dc.citation.number5-
dc.citation.startPage399-
dc.citation.endPage403-
dc.identifier.bibliographicCitationSCANDINAVIAN JOURNAL OF RHEUMATOLOGY, Vol.44(5) : 399-403, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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