Cited 17 times in
Serumleucine-richα2-glycoprotein is ausefulbiomarkerformonitoringdiseaseactivityinpatientswithadult-onsetStill'sdisease
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 이수곤 | - |
dc.date.accessioned | 2016-02-04T12:02:42Z | - |
dc.date.available | 2016-02-04T12:02:42Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0300-9742 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141766 | - |
dc.description.abstract | OBJECTIVE: To investigate whether serum leucine-rich α2-glycoprotein (LRG) levels are elevated in patients with adult-onset Still's disease (AOSD) and determine their correlation with disease activity parameters. METHOD: We enrolled 39 patients with AOSD, 47 patients with rheumatoid arthritis (RA), and 39 controls. Forty-five serum samples from the patients with AOSD were assayed for LRG using an enzyme-linked immunosorbent assay (ELISA). Comprehensive AOSD activity was determined by a modified Pouchot score. RESULTS: Serum LRG levels were significantly elevated in patients with AOSD (128.8 ± 40.8 ng/mL) compared to those in patients with RA and in controls (33.9 ± 15.2 ng/mL, p < 0.001 and 22.4 ± 6.1 ng/mL, p < 0.001, respectively). Patients with active AOSD had significantly higher LRG levels than those with inactive disease (141.4 ± 31.3 ng/mL vs. 79.8 ± 37.1 ng/mL, p = 0.002). Serum LRG levels were positively correlated with C-reactive protein (CRP; γ = 0.387, p = 0.015), lactate dehydrogenase (LDH; γ = 0.370, p = 0.026), ferritin (γ = 0.687, p < 0.001) levels, and the modified Pouchot score (γ = 0.756, p < 0.001). Serum LRG levels decreased significantly after treatment in all six patients with active AOSD who had follow-up evaluations (p = 0.007). The best cut-off value for LRG to distinguish AOSD from RA was 67.9 ng/mL, with a sensitivity of 92.3% and a specificity of 97.9%. CONCLUSIONS: Serum LRG levels were increased in patients with AOSD and correlated well with disease activity measures. LRG may be a useful biomarker for distinguishing AOSD from RA and for monitoring the disease activity of AOSD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 399~403 | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | C-Reactive Protein/metabolism | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Disease Progression* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Ferritins/blood | - |
dc.subject.MESH | Glycoproteins/blood* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | L-Lactate Dehydrogenase/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Severity of Illness Index* | - |
dc.subject.MESH | Still's Disease, Adult-Onset/blood | - |
dc.subject.MESH | Still's Disease, Adult-Onset/diagnosis* | - |
dc.title | Serumleucine-richα2-glycoprotein is ausefulbiomarkerformonitoringdiseaseactivityinpatientswithadult-onsetStill'sdisease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Y-J Ha | - |
dc.contributor.googleauthor | E-J Kang | - |
dc.contributor.googleauthor | S-W Lee | - |
dc.contributor.googleauthor | Y-B Park | - |
dc.contributor.googleauthor | S-K Lee | - |
dc.contributor.googleauthor | J-S Song | - |
dc.contributor.googleauthor | ST Choi | - |
dc.identifier.doi | 10.3109/03009742.2015.1016103 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02889 | - |
dc.relation.journalcode | J02635 | - |
dc.identifier.eissn | 1502-7732 | - |
dc.identifier.pmid | 26079682 | - |
dc.identifier.url | http://www.tandfonline.com/doi/abs/10.3109/03009742.2015.1016103 | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Lee, Soo Kon | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Lee, Soo Kon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 44 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 399 | - |
dc.citation.endPage | 403 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, Vol.44(5) : 399-403, 2015 | - |
dc.identifier.rimsid | 30873 | - |
dc.type.rims | ART | - |
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