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Denosumab-related osteonecrosis of the jaw: a case report and management based on pharmacokinetics

Authors
 Tae min You  ;  Kang-Hee Lee  ;  Soo-Hyeon Lee  ;  Wonse Park 
Citation
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, Vol.120(5) : 548-553, 2015 
Journal Title
 ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 
ISSN
 2212-4403 
Issue Date
2015
MeSH
Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnosis* ; Bisphosphonate-Associated Osteonecrosis of the Jaw/therapy* ; Bone Density Conservation Agents/adverse effects* ; Bone Density Conservation Agents/pharmacokinetics* ; Breast Neoplasms/drug therapy ; Denosumab/adverse effects* ; Denosumab/pharmacokinetics* ; Female ; Humans ; Middle Aged
Abstract
Denosumab, a monoclonal antibody against the receptor activator for nuclear factor-kappa B ligand (RANKL), is a recently approved antiresorptive drug that suppresses osteoclast formation by targeting preosteclasts, in contrast to the traditional antiresorptive bisphosphonates that target mature osteoclasts. Osteonecrosis of the jaw (ONJ) is a well-known, if rare, side effect of bisphosphonate therapy; however, cases of ONJ have also been reported since 2010 in patients taking denosumab. We describe here a patient who developed ONJ while receiving denosumab; the pharmacokinetics of denosumab and bisphosphonates are discussed in the context of ONJ management.
Full Text
http://www.sciencedirect.com/science/article/pii/S2212440315010962
DOI
10.1016/j.oooo.2015.07.017
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
Yonsei Authors
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Lee, Kang Hee(이강희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141755
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