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Denosumab-related osteonecrosis of the jaw: a case report and management based on pharmacokinetics

Authors
 Tae min You ; Kang-Hee Lee ; Wonse Park ; Soo-Hyeon Lee 
Citation
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology, Vol.120(5) : 548~553, 2015 
Journal Title
 Oral Surgery Oral Medicine Oral Pathology Oral Radiology 
ISSN
 2212-4403 
Issue Date
2015
Abstract
Denosumab, a monoclonal antibody against the receptor activator for nuclear factor-kappa B ligand (RANKL), is a recently approved antiresorptive drug that suppresses osteoclast formation by targeting preosteclasts, in contrast to the traditional antiresorptive bisphosphonates that target mature osteoclasts. Osteonecrosis of the jaw (ONJ) is a well-known, if rare, side effect of bisphosphonate therapy; however, cases of ONJ have also been reported since 2010 in patients taking denosumab. We describe here a patient who developed ONJ while receiving denosumab; the pharmacokinetics of denosumab and bisphosphonates are discussed in the context of ONJ management.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141755
DOI
10.1016/j.oooo.2015.07.017
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Advanced General Dentistry
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S2212440315010962
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