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Effect of High-Dose Statin Therapy on Drug-Eluting Stent Strut Coverage

DC FieldValueLanguage
dc.contributor.author고영국-
dc.contributor.author김병극-
dc.contributor.author김정훈-
dc.contributor.author김중선-
dc.contributor.author신동호-
dc.contributor.author장양수-
dc.contributor.author최동훈-
dc.contributor.author홍명기-
dc.date.accessioned2016-02-04T12:01:49Z-
dc.date.available2016-02-04T12:01:49Z-
dc.date.issued2015-
dc.identifier.issn1079-5642-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141736-
dc.description.abstractOBJECTIVE: The influence of high-dose statin therapy on the serial stent healing process has not been fully investigated. Using optical coherence tomography, the effect of high-dose statin therapy on stent strut coverage was evaluated in drug-eluting stent-treated patients. APPROACH AND RESULTS: Sixty patients were randomly assigned to 2 groups according to the statin dose (atorvastatin 40 mg as high-dose statin therapy [n=29] versus pravastatin 20 mg as low-dose statin therapy [n=31]). Serial optical coherence tomographic evaluation post procedure and at the 3-month and 12-month follow-ups was performed in 50 patients with 54 stents (23 atorvastatin-treated patients versus 27 pravastatin-treated patients). The percentage of uncovered struts was defined as the ratio of uncovered struts/total struts. The primary end point was the percentage of uncovered struts at the 12-month follow-up. The secondary end point was the percentage of uncovered struts at the 3-month follow-up and the comparative percentage change (Δ) of uncovered struts at the 3- and 12-month follow-ups between the different dose statin therapies. The percentage of uncovered struts was 7.4% (range, 4.3%-10.4%) in atorvastatin-treated patients versus 10.6% (range, 5.7%-22.6%) in pravastatin-treated patients at the 3-month follow-up (P=0.13) and 1.3% (0.3%-3.8%) versus 2.5% (0.9%-9.7%), respectively, at the 12-month follow-up (P=0.01). The percentage Δ of uncovered struts from 3 to 12 months of follow-up was -7.9±8.5% in atorvastatin-treated patients versus -9.3±12.5% in pravastatin-treated patients (P=0.67). CONCLUSIONS: This study suggested that high-dose statin therapy might provide a beneficial effect for the vascular healing process after drug-eluting stent implantation.-
dc.description.statementOfResponsibilityopen-
dc.format.extent2460~2467-
dc.relation.isPartOfARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAtorvastatin Calcium/administration & dosage*-
dc.subject.MESHCoronary Angiography-
dc.subject.MESHCoronary Artery Disease/diagnosis-
dc.subject.MESHCoronary Artery Disease/therapy*-
dc.subject.MESHCoronary Vessels/diagnostic imaging-
dc.subject.MESHCoronary Vessels/drug effects*-
dc.subject.MESHCoronary Vessels/pathology-
dc.subject.MESHDrug-Eluting Stents*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPercutaneous Coronary Intervention/adverse effects-
dc.subject.MESHPercutaneous Coronary Intervention/instrumentation*-
dc.subject.MESHPravastatin/administration & dosage*-
dc.subject.MESHProspective Studies-
dc.subject.MESHProsthesis Design-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTime Factors-
dc.subject.MESHTomography, Optical Coherence-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVascular Remodeling/drug effects*-
dc.subject.MESHWound Healing/drug effects*-
dc.titleEffect of High-Dose Statin Therapy on Drug-Eluting Stent Strut Coverage-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung-Sun Kim-
dc.contributor.googleauthorJeong Hun Kim-
dc.contributor.googleauthorDong-Ho Shin-
dc.contributor.googleauthorByeong-Keuk Kim-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.identifier.doi10.1161/ATVBAHA.115.306037-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00127-
dc.contributor.localIdA00493-
dc.contributor.localIdA00961-
dc.contributor.localIdA02097-
dc.contributor.localIdA03448-
dc.contributor.localIdA04053-
dc.contributor.localIdA04391-
dc.contributor.localIdA00906-
dc.relation.journalcodeJ00238-
dc.identifier.eissn1524-4636-
dc.identifier.pmid26359512-
dc.identifier.urlhttp://atvb.ahajournals.org/content/35/11/2460.long-
dc.subject.keywordatorvastatin-
dc.subject.keywordfollow-up studies-
dc.subject.keywordlipoproteins-
dc.subject.keywordoptical coherence-
dc.subject.keywordpravastatin-
dc.subject.keywordstents-
dc.subject.keywordtomography-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameKim, Byeong Keuk-
dc.contributor.alternativeNameKim, Jeong Hun-
dc.contributor.alternativeNameKim, Jung Sun-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.contributor.affiliatedAuthorKim, Byeong Keuk-
dc.contributor.affiliatedAuthorKim, Jung Sun-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorKim, Jeong Hun-
dc.rights.accessRightsnot free-
dc.citation.volume35-
dc.citation.number11-
dc.citation.startPage2460-
dc.citation.endPage2467-
dc.identifier.bibliographicCitationARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol.35(11) : 2460-2467, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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