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Associations between serum 25-hydroxyvitamin D and bone mineral density and proximal femur geometry in Koreans: the Korean National Health and Nutrition Examination Survey (KNHANES) 2008-2009

DC FieldValueLanguage
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.contributor.author황세나-
dc.date.accessioned2016-02-04T12:00:47Z-
dc.date.available2016-02-04T12:00:47Z-
dc.date.issued2015-
dc.identifier.issn0937-941X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141697-
dc.description.abstractThe association between 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD) and proximal femur bone geometry was examined in the Korean population. A positive relationship between skeletal health and 25(OH)D levels was observed. However, there were no significant differences in skeletal health between the groups with 25(OH)D level of 50-75 nmol/L and greater than 75 nmol/L. INTRODUCTION: Vitamin D plays an important role in calcium and phosphate homeostasis and normal mineralization of bone. However, the optimal level of vitamin D for skeletal health has not been clearly established. We analyzed the associations between serum 25(OH)D and BMD and proximal femur bone geometry and determined the optimal 25(OH)D level. METHODS: This was a cross-sectional study of 10,062 participants (20-95 years, 4,455 men, 5,607 women) in the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) conducted from 2008 to 2009. Participants were divided into groups according to 25(OH)D level (<25, 25-50, 50-75, and ≥75 nmol/L). BMD and proximal femur geometric indices were measured. RESULTS: The group with 25(OH)D levels of 50-75 nmol/L had greater bone density values, with the exception of the lumbar spine, and also had greater femur neck cortical thickness, cross-sectional area, and cross-sectional moment of inertia, as well as a lesser buckling ratio than the groups with 25(OH)D level of 25-50 nmol/L and less than 25 nmol/L. However, there were no significant differences in BMD and proximal femur geometry properties between the groups with 50-75 nmol/L and greater than 75 nmol/L of 25(OH)D. CONCLUSION: The skeletal outcomes, including BMD and proximal femur geometric indices observed in this study, suggest that serum 25(OH)D levels of 50 to <75 nmol/L are optimal for skeletal health.-
dc.description.statementOfResponsibilityopen-
dc.format.extent163~171-
dc.relation.isPartOfOSTEOPOROSIS INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAbsorptiometry, Photon/methods-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnthropometry/methods-
dc.subject.MESHBone Density/physiology*-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHFemur/anatomy & histology*-
dc.subject.MESHFemur/physiology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHVitamin D/analogs & derivatives*-
dc.subject.MESHVitamin D/blood-
dc.subject.MESHVitamin D Deficiency/epidemiology-
dc.subject.MESHVitamin D Deficiency/pathology-
dc.subject.MESHVitamin D Deficiency/physiopathology-
dc.subject.MESHYoung Adult-
dc.titleAssociations between serum 25-hydroxyvitamin D and bone mineral density and proximal femur geometry in Koreans: the Korean National Health and Nutrition Examination Survey (KNHANES) 2008-2009-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorS. Hwang-
dc.contributor.googleauthorH. S. Choi-
dc.contributor.googleauthorK. M. Kim-
dc.contributor.googleauthorY. Rhee-
dc.contributor.googleauthorS. K. Lim-
dc.identifier.doi10.1007/s00198-014-2877-0-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.contributor.localIdA04468-
dc.relation.journalcodeJ02451-
dc.identifier.eissn1433-2965-
dc.identifier.pmid25262060-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00198-014-2877-0-
dc.subject.keywordBone geometry-
dc.subject.keywordBone mineral density-
dc.subject.keywordPopulation study-
dc.subject.keywordVitamin D-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameHwang, Se Na-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorHwang, Se Na-
dc.rights.accessRightsnot free-
dc.citation.volume26-
dc.citation.number1-
dc.citation.startPage163-
dc.citation.endPage171-
dc.identifier.bibliographicCitationOSTEOPOROSIS INTERNATIONAL, Vol.26(1) : 163-171, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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