Cited 5 times in
Association Between 5-HTTLPR Polymorphism and Tics after Treatment with Methylphenidate in Korean Children with Attention-Deficit/Hyperactivity Disorder.
DC Field | Value | Language |
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dc.contributor.author | 김은주 | - |
dc.contributor.author | 박서연 | - |
dc.contributor.author | 천근아 | - |
dc.date.accessioned | 2016-02-04T12:00:08Z | - |
dc.date.available | 2016-02-04T12:00:08Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1044-5463 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141673 | - |
dc.description.abstract | OBJECTIVES: The purpose of this study is to examine the relationship between 5-HTTLPR polymorphism (44-bp insertion/deletion polymorphism of serotonin transporter gene) and methylphenidate (MPH) treatment response, as well as the association between the adverse events of MPH treatment and 5-HTTLPR polymorphism in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: A total of 114 children with ADHD (mean age 9.08 ± 1.94 years) were recruited from the child psychiatric clinic in a hospital in South Korea. We have extracted the genomic DNA of the subjects from their blood lymphocytes and analyzed 5-HTTLPR polymorphism of the SLC6A4 gene. All children were treated with MPH for 8 weeks, with clinicians monitoring both the improvement of ADHD symptoms and the side effects. We compared the response to MPH treatment and adverse events among those with the genotype of 5-HRRLPR polymorphism. RESULTS: There was no significant association between the 5-HTTLPR genotype and the response to MPH treatment in children with ADHD. Subjects with the S/L+L/L genotype tended to have tics and nail biting (respectively, p < 0.001, p = 0.017). CONCLUSIONS: The results of this study do not support the association between the 5-HTTLPR polymorphism and treatment response with MPH in ADHD. However, our findings suggest the association between 5-HTTLPR polymorphism and the occurrence of tics and nail-biting as an adverse event of methylphenidate. This may aid in our understanding of the genetic contribution and genetic susceptibility of a particular allele in those ADHD patients with tics or nail biting. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 633~640 | - |
dc.relation.isPartOf | JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Association Between 5-HTTLPR Polymorphism and Tics after Treatment with Methylphenidate in Korean Children with Attention-Deficit/Hyperactivity Disorder. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Seo Yeon Park | - |
dc.contributor.googleauthor | Eun Joo Kim | - |
dc.contributor.googleauthor | Keun-Ah Cheon | - |
dc.identifier.doi | 10.1089/cap.2014.0168 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00820 | - |
dc.contributor.localId | A01493 | - |
dc.contributor.localId | A04027 | - |
dc.relation.journalcode | J01310 | - |
dc.identifier.eissn | 1557-8992 | - |
dc.contributor.alternativeName | Kim, Eun Joo | - |
dc.contributor.alternativeName | Park, Seo Yeon | - |
dc.contributor.alternativeName | Cheon, Keun Ah | - |
dc.contributor.affiliatedAuthor | Kim, Eun Joo | - |
dc.contributor.affiliatedAuthor | Park, Seo Yeon | - |
dc.contributor.affiliatedAuthor | Cheon, Keun Ah | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 633 | - |
dc.citation.endPage | 640 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, Vol.25(8) : 633-640, 2015 | - |
dc.identifier.rimsid | 30807 | - |
dc.type.rims | ART | - |
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