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Association Between 5-HTTLPR Polymorphism and Tics after Treatment with Methylphenidate in Korean Children with Attention-Deficit/Hyperactivity Disorder.

DC FieldValueLanguage
dc.contributor.author김은주-
dc.contributor.author박서연-
dc.contributor.author천근아-
dc.date.accessioned2016-02-04T12:00:08Z-
dc.date.available2016-02-04T12:00:08Z-
dc.date.issued2015-
dc.identifier.issn1044-5463-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141673-
dc.description.abstractOBJECTIVES: The purpose of this study is to examine the relationship between 5-HTTLPR polymorphism (44-bp insertion/deletion polymorphism of serotonin transporter gene) and methylphenidate (MPH) treatment response, as well as the association between the adverse events of MPH treatment and 5-HTTLPR polymorphism in children with attention-deficit/hyperactivity disorder (ADHD). METHODS: A total of 114 children with ADHD (mean age 9.08 ± 1.94 years) were recruited from the child psychiatric clinic in a hospital in South Korea. We have extracted the genomic DNA of the subjects from their blood lymphocytes and analyzed 5-HTTLPR polymorphism of the SLC6A4 gene. All children were treated with MPH for 8 weeks, with clinicians monitoring both the improvement of ADHD symptoms and the side effects. We compared the response to MPH treatment and adverse events among those with the genotype of 5-HRRLPR polymorphism. RESULTS: There was no significant association between the 5-HTTLPR genotype and the response to MPH treatment in children with ADHD. Subjects with the S/L+L/L genotype tended to have tics and nail biting (respectively, p < 0.001, p = 0.017). CONCLUSIONS: The results of this study do not support the association between the 5-HTTLPR polymorphism and treatment response with MPH in ADHD. However, our findings suggest the association between 5-HTTLPR polymorphism and the occurrence of tics and nail-biting as an adverse event of methylphenidate. This may aid in our understanding of the genetic contribution and genetic susceptibility of a particular allele in those ADHD patients with tics or nail biting.-
dc.description.statementOfResponsibilityopen-
dc.format.extent633~640-
dc.relation.isPartOfJOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAssociation Between 5-HTTLPR Polymorphism and Tics after Treatment with Methylphenidate in Korean Children with Attention-Deficit/Hyperactivity Disorder.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorSeo Yeon Park-
dc.contributor.googleauthorEun Joo Kim-
dc.contributor.googleauthorKeun-Ah Cheon-
dc.identifier.doi10.1089/cap.2014.0168-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00820-
dc.contributor.localIdA01493-
dc.contributor.localIdA04027-
dc.relation.journalcodeJ01310-
dc.identifier.eissn1557-8992-
dc.contributor.alternativeNameKim, Eun Joo-
dc.contributor.alternativeNamePark, Seo Yeon-
dc.contributor.alternativeNameCheon, Keun Ah-
dc.contributor.affiliatedAuthorKim, Eun Joo-
dc.contributor.affiliatedAuthorPark, Seo Yeon-
dc.contributor.affiliatedAuthorCheon, Keun Ah-
dc.rights.accessRightsfree-
dc.citation.volume25-
dc.citation.number8-
dc.citation.startPage633-
dc.citation.endPage640-
dc.identifier.bibliographicCitationJOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, Vol.25(8) : 633-640, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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