Cited 134 times in
A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury
DC Field | Value | Language |
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dc.contributor.author | 김희진 | - |
dc.date.accessioned | 2016-02-04T11:59:53Z | - |
dc.date.available | 2016-02-04T11:59:53Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0272-6386 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141664 | - |
dc.description.abstract | BACKGROUND: Acute kidney injury (AKI) is a serious global public health problem. We aimed to quantify the risk of AKI associated with estimated glomerular filtration rate (eGFR), albuminuria (albumin-creatinine ratio [ACR]), age, sex, and race (African American and white). STUDY DESIGN: Collaborative meta-analysis. SETTING & POPULATION: 8 general-population cohorts (1,285,049 participants) and 5 chronic kidney disease (CKD) cohorts (79,519 participants). SELECTION CRITERIA FOR STUDIES: Available eGFR, ACR, and 50 or more AKI events. PREDICTORS: Age, sex, race, eGFR, urine ACR, and interactions. OUTCOME: Hospitalized with or for AKI, using Cox proportional hazards models to estimate HRs of AKI and random-effects meta-analysis to pool results. RESULTS: 16,480 (1.3%) general-population cohort participants had AKI over a mean follow-up of 4 years; 2,087 (2.6%) CKD participants had AKI over a mean follow-up of 1 year. Lower eGFR and higher ACR were strongly associated with AKI. Compared with eGFR of 80mL/min/1.73m(2), the adjusted HR of AKI at eGFR of 45mL/min/1.73m(2) was 3.35 (95% CI, 2.75-4.07). Compared with ACR of 5mg/g, the risk of AKI at ACR of 300mg/g was 2.73 (95% CI, 2.18-3.43). Older age was associated with higher risk of AKI, but this effect was attenuated with lower eGFR or higher ACR. Male sex was associated with higher risk of AKI, with a slight attenuation in lower eGFR but not in higher ACR. African Americans had higher AKI risk at higher levels of eGFR and most levels of ACR. LIMITATIONS: Only 2 general-population cohorts could contribute to analyses by race; AKI identified by diagnostic code. CONCLUSIONS: Reduced eGFR and increased ACR are consistent strong risk factors for AKI, whereas associations of AKI with age, sex, and race may be weaker in more advanced stages of CKD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 591~601 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF KIDNEY DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Kidney Injury/diagnosis* | - |
dc.subject.MESH | Acute Kidney Injury/epidemiology* | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | African Americans/statistics & numerical data | - |
dc.subject.MESH | Age Distribution | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Albuminuria/diagnosis | - |
dc.subject.MESH | Albuminuria/epidemiology* | - |
dc.subject.MESH | Continental Population Groups/statistics & numerical data* | - |
dc.subject.MESH | European Continental Ancestry Group/statistics & numerical data | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate/physiology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Sex Distribution | - |
dc.subject.MESH | Young Adult | - |
dc.title | A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Morgan E. Grams | - |
dc.contributor.googleauthor | Yingying Sang | - |
dc.contributor.googleauthor | Shoshana H. Ballew | - |
dc.contributor.googleauthor | Ron T. Gansevoort | - |
dc.contributor.googleauthor | Heejin Kimm | - |
dc.contributor.googleauthor | Csaba P. Kovesdy | - |
dc.contributor.googleauthor | David Naimark | - |
dc.contributor.googleauthor | Cecilia Oien | - |
dc.contributor.googleauthor | David H. Smith | - |
dc.contributor.googleauthor | Josef Coresh | - |
dc.contributor.googleauthor | Mark J. Sarnak | - |
dc.contributor.googleauthor | Benedicte Stengel | - |
dc.contributor.googleauthor | Marcello Tonelli | - |
dc.identifier.doi | 10.1053/j.ajkd.2015.02.337 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01226 | - |
dc.relation.journalcode | J00089 | - |
dc.identifier.eissn | 1523-6838 | - |
dc.identifier.pmid | 25943717 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0272638615005302 | - |
dc.subject.keyword | Chronic Kidney Disease Prognosis Consortium | - |
dc.subject.keyword | Estimated glomerular filtration rate (eGFR) | - |
dc.subject.keyword | acute kidney injury (AKI) | - |
dc.subject.keyword | acute renal failure (ARF) | - |
dc.subject.keyword | age | - |
dc.subject.keyword | albumin-creatinine ratio (ACR) | - |
dc.subject.keyword | albuminuria | - |
dc.subject.keyword | meta-analysis | - |
dc.subject.keyword | proteinuria | - |
dc.subject.keyword | race/ethnicity | - |
dc.subject.keyword | renal function | - |
dc.subject.keyword | sex | - |
dc.contributor.alternativeName | Kimm, Hee Jin | - |
dc.contributor.affiliatedAuthor | Kimm, Hee Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 66 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 591 | - |
dc.citation.endPage | 601 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF KIDNEY DISEASES, Vol.66(4) : 591-601, 2015 | - |
dc.identifier.rimsid | 30801 | - |
dc.type.rims | ART | - |
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