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Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer

DC Field Value Language
dc.contributor.author김현기-
dc.contributor.author김호근-
dc.contributor.author노성훈-
dc.date.accessioned2016-02-04T11:59:35Z-
dc.date.available2016-02-04T11:59:35Z-
dc.date.issued2015-
dc.identifier.issn1976-2283-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141652-
dc.description.abstractBACKGROUND/AIMS: The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been debated. METHODS: The clinicopathologic parameters and survival outcomes of 203 MSI-high (MSI-H) and 261 microsatellite-stable (MSS) advanced gastric cancers (AGCs) were compared. Next, we compared the immunohistochemistry results for hMLH1 and hMSH2 with those of a polymerase chain reaction (PCR)-based method. Kaplan-Meier curves and a Cox proportional hazard regression model were used to conduct survival analyses. RESULTS: The MSI-H AGCs were correlated with older age (p<0.001), female gender (p=0.018), distal location (p<0.001), larger size (p=0.016), and intestinal type (p<0.001). Multivariate analysis revealed that the MSI-H phenotype was an independent favorable factor that was related to overall survival in patients with AGC (p<0.001). Compared with the PCR-based analysis, immunohistochemistry exhibited high sensitivity (91.1%) and specificity (98.5%) in the detection of MSI phenotypes. CONCLUSIONS: MSI-H gastric cancers have distinct clinicopathologic features and better prognoses, which suggests the necessity of MSI analysis in gastric cancer. Immunohistochemistry can be a useful and reliable screening method in the assessment of MSI status in gastric cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent629~635-
dc.relation.isPartOfGUT AND LIVER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry/statistics & numerical data*-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMicrosatellite Instability*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPhenotype-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSex Factors-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/mortality-
dc.titleUsefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorYoon Sung Bae-
dc.contributor.googleauthorHoguen Kim-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorHyunki Kim-
dc.identifier.doi10.5009/gnl15133-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01108-
dc.contributor.localIdA01183-
dc.contributor.localIdA01281-
dc.relation.journalcodeJ00954-
dc.identifier.eissn2005-1212-
dc.identifier.pmid26343070-
dc.subject.keywordGastric cancer-
dc.subject.keywordImmunohistochemistry-
dc.subject.keywordMicrosatellite instability-
dc.subject.keywordhMLH1-
dc.subject.keywordhMSH2-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.rights.accessRightsfree-
dc.citation.volume9-
dc.citation.number5-
dc.citation.startPage629-
dc.citation.endPage635-
dc.identifier.bibliographicCitationGUT AND LIVER, Vol.9(5) : 629-635, 2015-
dc.identifier.rimsid30793-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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