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The Effects of a High Fat Diet Containing Diacylglycerol on Bone in C57BL/6J Mice

DC FieldValueLanguage
dc.contributor.author임승길-
dc.date.accessioned2016-02-04T11:59:17Z-
dc.date.available2016-02-04T11:59:17Z-
dc.date.issued2015-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141641-
dc.description.abstractPURPOSE: In epidemiologic and animal studies, a high fat diet (HFD) has been shown to be associated with lower bone mineral density (BMD) and a higher risk of osteoporotic fractures. Meanwhile, consuming a HFD containing diacylglycerol (DAG) instead of triacylglycerol (TAG) is known to offer metabolically beneficial effects of reductions in body weight and abdominal fat. The purpose of this study was to investigate the effects of a HFD containing DAG (HFD-DAG) on bone in mice. MATERIALS AND METHODS: Four-week-old male C57BL/6J mice (n=39) were divided into three weight-matched groups based on diet type: a chow diet group, a HFD containing TAG (HFD-TAG) group, and a HFD-DAG group. After 20 weeks, body composition and bone microstructure were analyzed using dual energy X-ray absorptiometry and micro-computed tomography. Reverse transcription-polymerase chain reaction (PCR) and real-time PCR of bone marrow cells were performed to investigate the expressions of transcription factors for osteogenesis or adipogenesis. RESULTS: The HFD-DAG group exhibited lower body weight, higher BMD, and superior microstructural bone parameters, compared to the HFD-TAG group. The HFD-DAG group showed increased expression of Runx2 and decreased expression of PPARgamma in bone marrow cells, compared to the HFD-TAG group. The HFD-DAG group also had lower levels of plasma glucose, insulin, total cholesterol, and triglyceride than the HFD-TAG group. CONCLUSION: Compared to HFD-TAG, HFD-DAG showed beneficial effects on bone and bone metabolism in C57BL/6J mice.-
dc.description.statementOfResponsibilityopen-
dc.format.extent951~960-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAbsorptiometry, Photon-
dc.subject.MESHAdipogenesis-
dc.subject.MESHAnimals-
dc.subject.MESHBody Composition-
dc.subject.MESHBody Weight-
dc.subject.MESHBone Density/drug effects*-
dc.subject.MESHBone Marrow Cells/metabolism-
dc.subject.MESHDiet, High-Fat/adverse effects*-
dc.subject.MESHDietary Fats/pharmacology*-
dc.subject.MESHDiglycerides/administration & dosage-
dc.subject.MESHDiglycerides/adverse effects*-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHOsteogenesis/drug effects*-
dc.subject.MESHReal-Time Polymerase Chain Reaction-
dc.subject.MESHTriglycerides-
dc.subject.MESHX-Ray Microtomography-
dc.titleThe Effects of a High Fat Diet Containing Diacylglycerol on Bone in C57BL/6J Mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHan Seok Choi-
dc.contributor.googleauthorSu Jin Park-
dc.contributor.googleauthorZang Hee Lee-
dc.contributor.googleauthorSung-Kil Lim-
dc.identifier.doi10.3349/ymj.2015.56.4.951-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03375-
dc.relation.journalcodeJ02813-
dc.identifier.pmid26069116-
dc.subject.keywordHigh fat diet-
dc.subject.keywordbone metabolism-
dc.subject.keywordbone mineral density-
dc.subject.keyworddiacylglycerol-
dc.subject.keywordosteoporotic fractures-
dc.subject.keywordtriacylglycerol-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.rights.accessRightsfree-
dc.citation.volume56-
dc.citation.number4-
dc.citation.startPage951-
dc.citation.endPage960-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.56(4) : 951-960, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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