0 455

Cited 170 times in

Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas

DC Field Value Language
dc.contributor.author라선영-
dc.date.accessioned2016-02-04T11:58:44Z-
dc.date.available2016-02-04T11:58:44Z-
dc.date.issued2015-
dc.identifier.issn0017-5749-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141621-
dc.description.abstractOBJECTIVE: Differences in gastric cancer (GC) clinical outcomes between patients in Asian and non-Asian countries has been historically attributed to variability in clinical management. However, recent international Phase III trials suggest that even with standardised treatments, GC outcomes differ by geography. Here, we investigated gene expression differences between Asian and non-Asian GCs, and if these molecular differences might influence clinical outcome. DESIGN: We compared gene expression profiles of 1016 GCs from six Asian and three non-Asian GC cohorts, using a two-stage meta-analysis design and a novel biostatistical method (RUV-4) to adjust for technical variation between cohorts. We further validated our findings by computerised immunohistochemical analysis on two independent tissue microarray (TMA) cohorts from Asian and non-Asian localities (n=665). RESULTS: Gene signatures differentially expressed between Asians and non-Asian GCs were related to immune function and inflammation. Non-Asian GCs were significantly enriched in signatures related to T-cell biology, including CTLA-4 signalling. Similarly, in the TMA cohorts, non-Asian GCs showed significantly higher expression of T-cell markers (CD3, CD45R0, CD8) and lower expression of the immunosuppressive T-regulatory cell marker FOXP3 compared to Asian GCs (p<0.05). Inflammatory cell markers CD66b and CD68 also exhibited significant cohort differences (p<0.05). Exploratory analyses revealed a significant relationship between tumour immunity factors, geographic locality-specific prognosis, and postchemotherapy outcomes. CONCLUSIONS: Analyses of >1600 GCs suggest that Asian and non-Asian GCs exhibit distinct tumour immunity signatures related to T-cell function. These differences may influence geographical differences in clinical outcome, and the design of future trials particularly in immuno-oncology.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1721~1731-
dc.relation.isPartOfGUT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/drug therapy-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHAdenocarcinoma/immunology*-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStomach Neoplasms/drug therapy-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/immunology*-
dc.subject.MESHTranscriptome*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleSignatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSuling J Lin-
dc.contributor.googleauthorJohann A Gagnon-Bartsch-
dc.contributor.googleauthorIain Beehuat Tan-
dc.contributor.googleauthorSophie Earle-
dc.contributor.googleauthorLouise Ruff-
dc.contributor.googleauthorKatherine Pettinger-
dc.contributor.googleauthorBauke Ylstra-
dc.contributor.googleauthorNicole van Grieken-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorJu-Seog Lee-
dc.contributor.googleauthorJae Ho Cheong-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorToru Aoyama-
dc.contributor.googleauthorYohei Miyagi-
dc.contributor.googleauthorAkira Tsuburaya-
dc.contributor.googleauthorTakaki Yoshikawa-
dc.contributor.googleauthorJaffer A Ajani-
dc.contributor.googleauthorAlex Boussioutas-
dc.contributor.googleauthorKhay Guan Yeoh-
dc.contributor.googleauthorWei Peng Yong-
dc.contributor.googleauthorJimmy So-
dc.contributor.googleauthorJeeyun Lee-
dc.contributor.googleauthorWon Ki Kang-
dc.contributor.googleauthorSung Kim-
dc.contributor.googleauthorYoichi Kameda-
dc.contributor.googleauthorTomio Arai-
dc.contributor.googleauthorAxel zur Hausen-
dc.contributor.googleauthorTerence P Speed-
dc.contributor.googleauthorHeike I Grabsch-
dc.contributor.googleauthorPatrick Tan-
dc.identifier.doi10.1136/gutjnl-2014-308252-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ00953-
dc.identifier.eissn1468-3288-
dc.identifier.pmid25385008-
dc.identifier.urlhttp://gut.bmj.com/content/64/11/1721.long-
dc.subject.keywordGASTRIC CANCER-
dc.subject.keywordGENE EXPRESSION-
dc.subject.keywordIMMUNOLOGY-
dc.subject.keywordMOLECULAR MECHANISMS-
dc.subject.keywordMOLECULAR PATHOLOGY-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.rights.accessRightsnot free-
dc.citation.volume64-
dc.citation.number11-
dc.citation.startPage1721-
dc.citation.endPage1731-
dc.identifier.bibliographicCitationGUT, Vol.64(11) : 1721-1731, 2015-
dc.identifier.rimsid30771-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.