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Gel scaffolds of BMP-2-binding peptide amphiphile nanofibers for spinal arthrodesis

Authors
 Sungsoo S. Lee  ;  Erin L. Hsu  ;  Marco Mendoza  ;  Jason Ghodasra  ;  Michael S. Nickoli  ;  Amruta Ashtekar  ;  Mahesh Polavarapu  ;  Jacob Babu  ;  Rehan M. Riaz  ;  Joseph D. Nicolas  ;  David Nelson  ;  Sohaib Z. Hashmi  ;  Stuart R. Kaltz  ;  Jeffrey S. Earhart  ;  Bradley R. Merk  ;  Jeff S. McKee  ;  Shawn F. Bairstow  ;  Ramille N. Shah  ;  Wellington K. Hsu  ;  Samuel I. Stupp 
Citation
 Advanced Healthcare Materials, Vol.4(1) : 131-141, 2015 
Journal Title
 Advanced Healthcare Materials 
ISSN
 2192-2640 
Issue Date
2015
Abstract
Peptide amphiphile (PA) nanofibers formed by self-assembly can be customized for specific applications in regenerative medicine through the use of molecules that display bioactive signals on their surfaces. Here, the use of PA nanofibers with binding affinity for the bone promoting growth factor BMP-2 to create a gel scaffold for osteogenesis is reported. With the objective of reducing the amount of BMP-2 used clinically for successful arthrodesis in the spine, amounts of growth factor incorporated in the scaffolds that are 10 to 100 times lower than that those used clinically in collagen scaffolds are used. The efficacy of the bioactive PA system to promote BMP-2-induced osteogenesis in vivo is investigated in a rat posterolateral lumbar intertransverse spinal fusion model. PA nanofiber gels displaying BMP-2-binding segments exhibit superior spinal fusion rates relative to controls, effectively decreasing the required therapeutic dose of BMP-2 by 10-fold. Interestingly, a 42% fusion rate is observed for gels containing the bioactive nanofibers without the use of exogenous BMP-2, suggesting the ability of the nanofiber to recruit endogenous growth factor. Results obtained here demonstrate that bioactive biomaterials with capacity to bind specific growth factors by design are great targets for regenerative medicine.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141598
DOI
10.1002/adhm.201400129
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)
Yonsei Authors
이성수(Lee, Sung Soo)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1002/adhm.201400129/abstract
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