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Predictors of thyroid gland involvement in hypopharyngeal squamous cell carcinoma

DC FieldValueLanguage
dc.contributor.author고윤우-
dc.contributor.author장재원-
dc.contributor.author정웅윤-
dc.contributor.author최은창-
dc.contributor.author홍순원-
dc.date.accessioned2016-02-04T11:57:14Z-
dc.date.available2016-02-04T11:57:14Z-
dc.date.issued2015-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141566-
dc.description.abstractPURPOSE: Decision to perform concurrent ipsilateral thyroidectomy on patients with hypopharyngeal cancer is important, and unnecessary thyroidectomy should be avoided if oncologically feasible. We hypothesized that concurrent ipsilateral thyroidectomy is not routinely required to prevent occult metastasis. This study aimed to determine the prevalence of histological thyroid invasion in patients with hypopharyngeal cancer, and to refine the indications for prophylactic ipsilateral thyroidectomy in patients with hypopharyngeal cancer. MATERIALS AND METHODS: A retrospective review of the medical records from the Department of Otolaryngology at Yonsei University College of Medicine was conducted from January 1994 to December 2009. A total of 49 patients underwent laryngopharyngectomy with thyroidectomy as a primary treatment of hypopharyngeal cancer. RESULTS: The incidence of thyroid gland involvement was 10.2%. The most common route of invasion was direct extension through the thyroid cartilage. Thyroid cartilage invasion (p=0.034) was the most significant factor associated with thyroid invasion. Disease-specific survival at 5 years was lower in patients with than without thyroid gland invasion (26.7% vs. 55.2%, respectively; p=0.032). Disease-free survival at 5 years was also lower in patients with than without thyroid gland invasion (20.0% vs. 52.1%, respectively; p=0.024). CONCLUSION: Ipsilateral thyroidectomy in combination with total laryngopharyngectomy is indicated when invasion of the thyroid cartilage is suspected in patients with hypopharyngeal cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent812~818-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma, Squamous Cell/epidemiology-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCarcinoma, Squamous Cell/surgery*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHypopharyngeal Neoplasms/epidemiology-
dc.subject.MESHHypopharyngeal Neoplasms/pathology-
dc.subject.MESHHypopharyngeal Neoplasms/surgery*-
dc.subject.MESHIncidence-
dc.subject.MESHLaryngectomy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasms, Second Primary/epidemiology-
dc.subject.MESHNeoplasms, Second Primary/pathology-
dc.subject.MESHNeoplasms, Second Primary/surgery-
dc.subject.MESHPharyngectomy*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHThyroid Gland/pathology*-
dc.subject.MESHThyroid Gland/surgery-
dc.subject.MESHThyroid Neoplasms/epidemiology-
dc.subject.MESHThyroid Neoplasms/secondary*-
dc.subject.MESHThyroidectomy/methods*-
dc.titlePredictors of thyroid gland involvement in hypopharyngeal squamous cell carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorJae Won Chang-
dc.contributor.googleauthorYoon Woo Koh-
dc.contributor.googleauthorWoong Youn Chung-
dc.contributor.googleauthorSoon Won Hong-
dc.contributor.googleauthorEun Chang Choi-
dc.identifier.doi10.3349/ymj.2015.56.3.812-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00133-
dc.contributor.localIdA03465-
dc.contributor.localIdA03674-
dc.contributor.localIdA04161-
dc.contributor.localIdA04411-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid25837190-
dc.subject.keywordHypopharyngeal cancer-
dc.subject.keywordthyroid cartilage invasion-
dc.subject.keywordthyroidectomy-
dc.subject.keywordtotal laryngopharyngectomy-
dc.contributor.alternativeNameKho, Yoon Woo-
dc.contributor.alternativeNameChang, Jae Won-
dc.contributor.alternativeNameChung, Woung Youn-
dc.contributor.alternativeNameChoi, Eun Chang-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.affiliatedAuthorKho, Yoon Woo-
dc.contributor.affiliatedAuthorChang, Jae Won-
dc.contributor.affiliatedAuthorChung, Woung Youn-
dc.contributor.affiliatedAuthorChoi, Eun Chang-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.rights.accessRightsfree-
dc.citation.volume56-
dc.citation.number3-
dc.citation.startPage812-
dc.citation.endPage818-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.56(3) : 812-818, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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