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Pattern of care of anaplastic oligodendroglioma and oligoastrocytoma in a Korean population: the Korean Radiation Oncology Group study 13-12

DC FieldValueLanguage
dc.contributor.author서창옥-
dc.contributor.author조재호-
dc.date.accessioned2016-02-04T11:56:54Z-
dc.date.available2016-02-04T11:56:54Z-
dc.date.issued2015-
dc.identifier.issn0167-594X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141554-
dc.description.abstractThis study investigated the treatment of anaplastic oligodendroglial tumors across nine Korean institutions. We reviewed the medical records from 381 patients with histologically confirmed anaplastic oligodendroglioma or anaplastic oligoastrocytoma (AOA) from 2000 to 2010. Clinical factors and treatment patterns were analyzed for each year. Post-operative therapy was performed in 354 patients (94.1 %), of which 133 received radiotherapy (RT) alone and 189 received both RT and chemotherapy. RT alone was the preferred treatment toward the end of the study period (29.4 % in 2000-2001 vs. 56.3 % in 2010, P = 0.005). The use of procarbazine, lomustine, and vincristine (PCV) decreased (57.6 % in 2000-2001 vs. 28.6 % in 2010, P = 0.001) and the use of temozolomide (TMZ) increased (0 % in 2000-2001 vs. 61.9 % in 2010, P < 0.001) over the study period. A combination of chemotherapy and RT was used more often than RT alone in young patients (P = 0.036) and patients with a good performance status (P = 0.023). The 1p/19q co-deletion status and O-6-methyguanine-DNA methyltransferase methylation were analyzed since 2004 but were not significant factors for determining whether to administer chemotherapy. Among the patients who received chemotherapy, TMZ was used more often in patients with AOA (P = 0.007) and PCV was used more often in patients with either multiple lesions (P = 0.027) or the 1p/19q co-deletion (P = 0.026). Our results demonstrate that the treatment pattern for oligodendroglial tumors changed significantly across the study period. In particular, TMZ has replaced PCV, and the use of molecular markers as well as RT alone has increased, but a unified protocol remains to be established.-
dc.description.statementOfResponsibilityopen-
dc.format.extent531~539-
dc.relation.isPartOfJournal of Neuro-Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePattern of care of anaplastic oligodendroglioma and oligoastrocytoma in a Korean population: the Korean Radiation Oncology Group study 13-12-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorTosol Yu-
dc.contributor.googleauthorHyun Cheol Kang-
dc.contributor.googleauthorDo Hoon Lim-
dc.contributor.googleauthorIl Han Kim-
dc.contributor.googleauthorWoong Ki Chung-
dc.contributor.googleauthorChang Ok Suh-
dc.contributor.googleauthorByung Ock Choi-
dc.contributor.googleauthorKwan Ho Cho-
dc.contributor.googleauthorJae Ho Cho-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorChul Kee Park-
dc.contributor.googleauthorYong Kil Hong-
dc.contributor.googleauthorIn Ah Kim-
dc.identifier.doi10.1007/s11060-014-1660-6-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03901-
dc.contributor.localIdA01919-
dc.relation.journalcodeJ01629-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs11060-014-1660-6-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameCho, Jae Ho-
dc.contributor.affiliatedAuthorCho, Jae Ho-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.rights.accessRightsnot free-
dc.citation.volume121-
dc.citation.number3-
dc.citation.startPage531-
dc.citation.endPage539-
dc.identifier.bibliographicCitationJournal of Neuro-Oncology, Vol.121(3) : 531-539, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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