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Cited 23 times in

LAMC2 enhances the metastatic potential of lung adenocarcinoma

DC FieldValueLanguage
dc.contributor.author정현철-
dc.contributor.author김주항-
dc.contributor.author문용화-
dc.contributor.author심효섭-
dc.date.accessioned2016-02-04T11:55:02Z-
dc.date.available2016-02-04T11:55:02Z-
dc.date.issued2015-
dc.identifier.issn1350-9047-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141484-
dc.description.abstractLung cancer is the number one cancer killer, and metastasis is the main cause of high mortality in lung cancer patients. However, mechanisms underlying the development of lung cancer metastasis remain unknown. Using genome-wide transcriptional analysis in an experimental metastasis model, we identified laminin γ2 (LAMC2), an epithelial basement membrane protein, to be significantly upregulated in lung adenocarcinoma metastatic cells. Elevated LAMC2 increased traction force, migration, and invasion of lung adenocarcinoma cells accompanied by the induction of epithelial-mesenchymal transition (EMT). LAMC2 knockdown decreased traction force, migration, and invasion accompanied by EMT reduction in vitro, and attenuated metastasis in mice. LAMC2 promoted migration and invasion via EMT that was integrin β1- and ZEB1-dependent. High LAMC2 was significantly correlated with the mesenchymal marker vimentin expression in lung adenocarcinomas, and with higher risk of recurrence or death in patients with lung adenocarcinoma. We suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT and may be a potential therapeutic target.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1341~1352-
dc.relation.isPartOfCELL DEATH AND DIFFERENTIATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/metabolism*-
dc.subject.MESHAdenocarcinoma/pathology*-
dc.subject.MESHAnimals-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Movement/genetics-
dc.subject.MESHCell Movement/physiology-
dc.subject.MESHEpithelial-Mesenchymal Transition/genetics-
dc.subject.MESHEpithelial-Mesenchymal Transition/physiology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLaminin/genetics-
dc.subject.MESHLaminin/metabolism*-
dc.subject.MESHLung Neoplasms/metabolism*-
dc.subject.MESHLung Neoplasms/pathology*-
dc.subject.MESHMice-
dc.titleLAMC2 enhances the metastatic potential of lung adenocarcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorY W Moon-
dc.contributor.googleauthorG Rao-
dc.contributor.googleauthorJ J Kim-
dc.contributor.googleauthorH-S Shim-
dc.contributor.googleauthorK-S Park-
dc.contributor.googleauthorS S An-
dc.contributor.googleauthorB Kim-
dc.contributor.googleauthorP S Steeg-
dc.contributor.googleauthorS Sarfaraz-
dc.contributor.googleauthorL Changwoo Lee-
dc.contributor.googleauthorDonna Voeller-
dc.contributor.googleauthorE Y Choi-
dc.contributor.googleauthorJi Luo-
dc.contributor.googleauthorD Palmieri-
dc.contributor.googleauthorH C Chung-
dc.contributor.googleauthorJ-H Kim-
dc.contributor.googleauthorY Wang-
dc.contributor.googleauthorG Giaccone-
dc.identifier.doi10.1038/cdd.2014.228-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03773-
dc.contributor.localIdA00945-
dc.contributor.localIdA01370-
dc.contributor.localIdA02219-
dc.relation.journalcodeJ00483-
dc.identifier.eissn1476-5403-
dc.identifier.pmid25591736-
dc.identifier.urlhttp://www.nature.com/cdd/journal/v22/n8/full/cdd2014228a.html-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameKim, Joo Hang-
dc.contributor.alternativeNameMoon, Yong Wha-
dc.contributor.alternativeNameShim, Hyo Sup-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorKim, Joo Hang-
dc.contributor.affiliatedAuthorMoon, Yong Wha-
dc.contributor.affiliatedAuthorShim, Hyo Sup-
dc.rights.accessRightsnot free-
dc.citation.volume22-
dc.citation.number8-
dc.citation.startPage1341-
dc.citation.endPage1352-
dc.identifier.bibliographicCitationCELL DEATH AND DIFFERENTIATION, Vol.22(8) : 1341-1352, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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