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Topographical variation of macular choroidal thickness with myopia

 Kwanghyun Lee  ;  Junwon Lee  ;  Christopher S. Lee  ;  Sun Young Park  ;  Sung Chul Lee  ;  TaekJune Lee 
 ACTA OPHTHALMOLOGICA, Vol.93(6) : 469-474, 2015 
Journal Title
Issue Date
Adult ; Aged ; Axial Length, Eye/pathology ; Choroid/pathology* ; Cross-Sectional Studies ; Female ; Fovea Centralis ; Humans ; Male ; Middle Aged ; Myopia/classification ; Myopia/physiopathology* ; Organ Size ; Retrospective Studies ; Severity of Illness Index ; Tomography, Optical Coherence ; Visual Acuity ; Young Adult
choroidal thickness ; myopia ; normal subjects ; peripapillary atrophy
PURPOSE: To study the association between topographical variation of choroidal thickness and myopic features in healthy eyes, using spectral domain optical coherence tomography (OCT). METHODS: Choroidal thickness was measured at the foveal centre (CTF) and 1.5 mm superiorly (CTS), inferiorly (CTI), nasally (CTN) and temporally (CTT) from the foveal centre, using enhanced depth imaging OCT. The temporal width of β zone of peripapillary atrophy (βPPA) was measured on infrared fundus images. The ratio of βPPA width to vertical disc diameter (PVDR) was calculated to correct retinal magnification. RESULTS: This study includes 85 eyes from 85 subjects who had a mean age of 53.9 ± 12.9 years, a mean axial length of 23.56 ± 0.82 mm, a mean refractive error of -0.14 ± 1.80 D, a mean βPPA width of 218.6 ± 181.3 μm and a mean PVDR of 0.13 ± 0.11. The CTF was thickest (266.4 ± 81.6), followed by CTS (256.2 ± 82.5 μm), CTT (251.7 ± 68.4 μm), CTI (247.7 ± 90.3 μm) and CTN (211.0 ± 76.5 μm). There were 31 eyes (36.5%) with CTT thicker than CTF. The CTT/CTF negatively correlated with refractive error (p = 0.012) and positively correlated with axial length (p = 0.031), βPPA width (p = 0.003) and PVDR (p = 0.006). CONCLUSIONS: There was a correlation between a thickened choroid, temporal to the foveal centre, with the severity of myopic components in normal eyes. Topographical changes might be induced by stretching of the choroid and sclera towards a temporal direction with eyeball elongation.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
Lee, Christopher Seungkyu(이승규) ORCID logo https://orcid.org/0000-0001-5054-9470
Lee, Jun Won(이준원) ORCID logo https://orcid.org/0000-0003-0543-7132
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