Cited 5 times in
Circulating Anti-Elastin Antibody Levels and Arterial Disease Characteristics: Associations with Arterial Stiffness and Atherosclerosis.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강석민 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 이승현 | - |
dc.date.accessioned | 2016-02-04T11:54:25Z | - |
dc.date.available | 2016-02-04T11:54:25Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/141462 | - |
dc.description.abstract | PURPOSE: Elastin is a major arterial structural protein, and elastin-derived peptides are related to arterial change. We previously reported on a novel assay developed using aortic elastin peptides; however, its clinical implications remain unclear. In this study, we assessed whether anti-elastin antibody titers reflect the risk of coronary artery disease (CAD) or its characteristics. MATERIALS AND METHODS: We included 174 CAD patients and 171 age- and sex-matched controls. Anti-elastin antibody titers were quantified by enzyme-linked immunosorbent assay. Parameters of arterial stiffness, including the augmentation index (AI) and heart-to-femoral pulse wave velocity (hfPWV), were measured non-invasively. The clinical and angiographic characteristics of CAD patients were also evaluated. Associations between anti-elastin levels and vascular characteristics were examined by linear regression analysis. RESULTS: The median blood level of anti-elastin was significantly lower in the CAD group than in the controls [197 arbitrary unit (a.u.) vs. 63 a.u., p<0.001]. Levels of anti-elastin were significantly lower in men and in subjects with hypertension, diabetes mellitus, hyperlipidemia, or high hfPWV. Nevertheless, anti-elastin levels were not dependent on atherothrombotic events or the angiographic severity of CAD. In a multivariate analysis, male sex (β=-0.38, p<0.001), diabetes mellitus (β=-0.62, p<0.001), hyperlipidemia (β=-0.29, p<0.001), and AI (β=-0.006, p=0.02) were ultimately identified as determinants of anti-elastin levels. CONCLUSION: Lower levels of anti-elastin are related to CAD. The association between antibody titers and CAD is linked to arterial stiffness rather than the advancement of atherosclerosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Angiography | - |
dc.subject.MESH | Antibodies/blood* | - |
dc.subject.MESH | Atherosclerosis/blood* | - |
dc.subject.MESH | Atherosclerosis/immunology | - |
dc.subject.MESH | Coronary Artery Disease/blood | - |
dc.subject.MESH | Coronary Artery Disease/immunology* | - |
dc.subject.MESH | Elastin/blood* | - |
dc.subject.MESH | Elastin/immunology | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperlipidemias | - |
dc.subject.MESH | Hypertension/complications | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pulse Wave Analysis | - |
dc.subject.MESH | Vascular Stiffness/immunology* | - |
dc.subject.MESH | Vascular Stiffness/physiology | - |
dc.title | Circulating Anti-Elastin Antibody Levels and Arterial Disease Characteristics: Associations with Arterial Stiffness and Atherosclerosis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Seung-Hyun Lee | - |
dc.contributor.googleauthor | Kihyuk Shin | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Seung-Hyo Lee | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.identifier.doi | 10.3349/ymj.2015.56.6.1545 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A02833 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 26446635 | - |
dc.subject.keyword | Elastin | - |
dc.subject.keyword | antibody formation | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | coronary artery disease | - |
dc.subject.keyword | vascular stiffness | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.alternativeName | Lee, Sang Hak | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Snag Hak | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 56 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1541 | - |
dc.citation.endPage | 1551 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.56(6) : 1541-1551, 2015 | - |
dc.identifier.rimsid | 30659 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.