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Circulating Anti-Elastin Antibody Levels and Arterial Disease Characteristics: Associations with Arterial Stiffness and Atherosclerosis.

DC FieldValueLanguage
dc.contributor.author강석민-
dc.contributor.author박성하-
dc.contributor.author이상학-
dc.contributor.author최동훈-
dc.contributor.author이승현-
dc.date.accessioned2016-02-04T11:54:25Z-
dc.date.available2016-02-04T11:54:25Z-
dc.date.issued2015-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/141462-
dc.description.abstractPURPOSE: Elastin is a major arterial structural protein, and elastin-derived peptides are related to arterial change. We previously reported on a novel assay developed using aortic elastin peptides; however, its clinical implications remain unclear. In this study, we assessed whether anti-elastin antibody titers reflect the risk of coronary artery disease (CAD) or its characteristics. MATERIALS AND METHODS: We included 174 CAD patients and 171 age- and sex-matched controls. Anti-elastin antibody titers were quantified by enzyme-linked immunosorbent assay. Parameters of arterial stiffness, including the augmentation index (AI) and heart-to-femoral pulse wave velocity (hfPWV), were measured non-invasively. The clinical and angiographic characteristics of CAD patients were also evaluated. Associations between anti-elastin levels and vascular characteristics were examined by linear regression analysis. RESULTS: The median blood level of anti-elastin was significantly lower in the CAD group than in the controls [197 arbitrary unit (a.u.) vs. 63 a.u., p<0.001]. Levels of anti-elastin were significantly lower in men and in subjects with hypertension, diabetes mellitus, hyperlipidemia, or high hfPWV. Nevertheless, anti-elastin levels were not dependent on atherothrombotic events or the angiographic severity of CAD. In a multivariate analysis, male sex (β=-0.38, p<0.001), diabetes mellitus (β=-0.62, p<0.001), hyperlipidemia (β=-0.29, p<0.001), and AI (β=-0.006, p=0.02) were ultimately identified as determinants of anti-elastin levels. CONCLUSION: Lower levels of anti-elastin are related to CAD. The association between antibody titers and CAD is linked to arterial stiffness rather than the advancement of atherosclerosis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAngiography-
dc.subject.MESHAntibodies/blood*-
dc.subject.MESHAtherosclerosis/blood*-
dc.subject.MESHAtherosclerosis/immunology-
dc.subject.MESHCoronary Artery Disease/blood-
dc.subject.MESHCoronary Artery Disease/immunology*-
dc.subject.MESHElastin/blood*-
dc.subject.MESHElastin/immunology-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyperlipidemias-
dc.subject.MESHHypertension/complications-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPulse Wave Analysis-
dc.subject.MESHVascular Stiffness/immunology*-
dc.subject.MESHVascular Stiffness/physiology-
dc.titleCirculating Anti-Elastin Antibody Levels and Arterial Disease Characteristics: Associations with Arterial Stiffness and Atherosclerosis.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSeung-Hyun Lee-
dc.contributor.googleauthorKihyuk Shin-
dc.contributor.googleauthorSang-Hak Lee-
dc.contributor.googleauthorSeung-Hyo Lee-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorSungha Park-
dc.identifier.doi10.3349/ymj.2015.56.6.1545-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00037-
dc.contributor.localIdA01512-
dc.contributor.localIdA04053-
dc.contributor.localIdA02833-
dc.relation.journalcodeJ02813-
dc.identifier.pmid26446635-
dc.subject.keywordElastin-
dc.subject.keywordantibody formation-
dc.subject.keywordatherosclerosis-
dc.subject.keywordcoronary artery disease-
dc.subject.keywordvascular stiffness-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.alternativeNamePark, Sung Ha-
dc.contributor.alternativeNameLee, Sang Hak-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.affiliatedAuthorKang, Seok Min-
dc.contributor.affiliatedAuthorPark, Sung Ha-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorLee, Snag Hak-
dc.rights.accessRightsfree-
dc.citation.volume56-
dc.citation.number6-
dc.citation.startPage1541-
dc.citation.endPage1551-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.56(6) : 1541-1551, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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